Feel the vibe, feel the terror, feel the pain
•
• Mad about you, orchestrally.
• more quotes

very clickable

π day
·
ASCII
·
choices
·
clocks
·
color
·
covers
^{NEW}
·
deadly genomes
^{NEW}
·
debates
·
famous rat
·
gigapixel skies
^{NEW}
·
hitchens
·
huge voids
·
keyboards
·
languages
·
LOTRO
·
photography
·
questions
·
quotes
·
road trips
·
rockets
·
satire
·
sky constellations
^{NEW}
·
spam poetry
·
time
·
tripsum
·
type
·
unwords
·
words
·
writing
·
zaomm

visualization
**+** math

Numbers are a lot of fun. They can start conversations—the interesting number paradox is a party favourite: every number must be interesting because the first number that wasn't would be very interesting! Of course, in the wrong company they can just as easily end conversations.

The art here is my attempt at transforming famous numbers in mathematics into pretty visual forms, start some of these conversations and awaken emotions for mathematics—other than dislike and confusion

Numerology is bogus, but art based on numbers can be beautiful. Proclus got it right when he said (as quoted by M. Kline in *Mathematical Thought from Ancient to Modern Times*)

Wherever there is number, there is beauty.

—Proclus Diadochus

The consequence of the interesting number paradox is that all numbers are interesting. But some are more interesting than others—how Orwellian!

All animals are equal, but some animals are more equal than others.

—George Orwell (Animal Farm)

Numbers such as `\pi` (or `\tau` if you're a revolutionary), `\phi`, `e`, `i = \sqrt{-1}`, and `0` have captivated imagination. Chances are at least one of them appears in the next physics equation you come across.

π φ e

= 3.14159 26535 89793 23846 26433 83279 50288 41971 69399 ... = 1.61803 39887 49894 84820 45868 34365 63811 77203 09179 ... = 2.71828 18284 59045 23536 02874 71352 66249 77572 47093 ...

Of these three transcendental numbers, `\pi` (3.14159265...) is the most well known. It is the ratio of a circle's circumference to its diameter (`d = \pi r`) and appears in the formula for the area of the circle (`a = \pi r^2`).

The Golden Ratio (`\phi`, 1.61803398...) is the attractive proportion of values `a > b` that satisfy `{a+b}/2 = a/b`, which solves to `a/b = {1 + \sqrt{5}}/2`.

The last of the three numbers, `e` (2.71828182...) is Euler's number and also known as the base of the natural logarithm. It, too, can be defined geometrically—it is the unique real number, `e`, for which the function `f(x) = e^x` has a tangent of slope 1 at `x=0`. Like `\pi`, `e` appears throughout mathematics. For example, `e` is central in the expression for the normal distribution as well as the definition of entropy. And if you've ever heard of someone talking about log plots ... well, there's `e` again!

Two of these numbers can be seen together in mathematics' most beautiful equation, the Euler identity: `e^{i\pi} = -1`. The tau-oists would argue that this is even prettier: `e^{i\tau} = 1`.

Did you notice how the 13th digit of all three numbers is the same (9)? This accidental similarity generates its own number—the Accidental Similarity Number (ASN).

news
**+** thoughts

Our cover on the 11 January 2023 Cell Genomics issue depicts the process of determining the parent-of-origin using differential methylation of alleles at imprinted regions (iDMRs) is imagined as a circuit.

Designed in collaboration with with Carlos Urzua.

Akbari, V. *et al.* Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq (2023) Cell Genomics 3(1).

Browse my gallery of cover designs.

My cover design on the 6 January 2023 Science Advances issue depicts DNA sequencing read translation in high-dimensional space. The image showss 672 bases of sequencing barcodes generated by three different single-cell RNA sequencing platforms were encoded as oriented triangles on the faces of three 7-dimensional cubes.

More details about the design.

Kijima, Y. *et al.* A universal sequencing read interpreter (2023) *Science Advances* **9**

Browse my gallery of cover designs.

*If you sit on the sofa for your entire life, you’re running a higher risk of getting heart disease and cancer. —Alex Honnold, American rock climber*

In a follow-up to our Survival analysis — time-to-event data and censoring article, we look at how regression can be used to account for additional risk factors in survival analysis.

We explore accelerated failure time regression (AFTR) and the Cox Proportional Hazards model (Cox PH).

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Regression modeling of time-to-event data with censoring. *Nature Methods* **19**.

My 5-dimensional animation sets the visual stage for Max Cooper's *Ascent* from the album *Unspoken Words*. I have previously collaborated with Max on telling a story about infinity for his *Yearning for the Infinite* album.

I provide a walkthrough the video, describe the animation system I created to generate the frames, and show you all the keyframes

The video recently premiered on YouTube.

Renders of the full scene are available as NFTs.

*I am more than my genome and my genome is more than me.*

The MIT Museum reopened at its new location on 2nd October 2022. The new Gene Cultures exhibit featured my visualization of the human genome, which walks through the size and organization of the genome and some of the important structures.

My cover design on the 1 September 2022 Annals of Oncology issue shows 570 individual cases of difficult-to-treat cancers. Each case shows the number and type of actionable genomic alterations that were detected and the length of therapies that resulted from the analysis.

Pleasance E *et al.* Whole-genome and transcriptome analysis enhances precision cancer treatment options (2022) *Annals of Oncology* **33**:939–949.

Browse my gallery of cover designs.

© 1999–2023 Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences Centre ⊂ BC Cancer Research Center ⊂ BC Cancer ⊂ PHSA