resources
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lunch break
Distractions and amusements, with a sandwich and coffee.
visualization + design
The art of Pi (`\pi`), Phi (`\phi`) and `e`
Like music with numbers? Here's a short list of some of my favourite songs that have numbers in their lyrics. Absolutely none of them is about bottles of beer.
music with numbers
1 — Numbers, Smoke City | This song is entirely composed of references to different numbers. The bonus? It's both in English and Portuguese. I love the way it ends—"Isn't it beautiful out here?".
Un
Un
Four
Five
Fifteen
Quinze
Seventeen
Seven
...
Tres
forty nine
Isn't it beautiful out here?
Isn't it beautiful out here?
Isn't it beautiful out here?
2 — 99 luftbaloons, Nena | The numerical classic.
Hast du etwas Zeit für mich
Dann singe ich ein Lied für dich
Von 99 Luftballons
3 — One, Aimee Mann | Beautiful mathematics of relationships using small numbers.
One is the lonliest number that you'll ever do. Two can be as bad as one, it's the lonliest number since the number one.
4 — Angels at My Door, Una | Long sequences of numbers.
58, 56, 54 angels at my door.
63, 62, 61, 60, 59, 58 angels at my gate.
5 — Tricky, Tricky, Royksopp | Number words about the fearful six from Norway.
Six afraid of seven 'cause seven, eight, nine
I'm about to lose it the second time
6 — Pt vs Ys, Yoshinori Sunahara | The first four numbers, in German, are this song's lyrics.
Eins, zwei, drei, vier.
7 — Der Kommissar, Falco | Unlike the previous song, this one starts with a German count (doesn't get to vier, though) and just gets better from there.
Two, three, four
Eins, zwei, drei
Na, es is nix dabei
Na, wenn ich euch erzähl' die G'schicht'
8 — 2wicky, Hooverphonic | The numbers likely reference the Prophet-600 and SH-101 synthesizers.
Prophet 60091.
Before we start you should know that you're not the only one who can hurt me.
SH10151.
This is the serial number of our orbital gun.
SH10151.
You better be sure before you leave me for another one.
9 — Straight to Number One, Touch and Go | Something to listen to after midnight.
Fingers, four, play, three, to number one.
10 — The Beat Experience, Pepe Deluxe | I am reminded of this song at too many academic seminars.
Here we are now, at the middle, of the fourth large part of this talk.
More and more I have the feeling that we are getting nowhere.
Slowly, as the talk goes on, we are getting nowhere.
And that is a pleasure.
It is not irritating where one is.
It is only irritating to think one would like to be somewhere else.
Here we are now, a little bit after the middle, of the fourth large part of this talk.
11 — Thousand Kisses Deep, Leonard Cohen | A list of songs that doesn't include one by Cohen is not worth reading. The sentiment of a thousand kisses is as old as lips existed. Catullus wrote to Lesbia "da mi basia mille, deinde centum, dein mille altera, dein secunda centum, deinde usque altera mille, deinde centum" [Give me a thousand kisses, then a hundred, then another thousand, then a second hundred, then yet another thousand, then a hundred.] Well, you get the idea.
And sometimes when the night is slow,
The wretched and the meek,
We gather up our hearts and go,
A Thousand Kisses Deep.
12 — Six Seven Times, Flunk | Curiously the product here is 42. This song is the answer to life.
You've got it all
Six seven times
You've got it all
Makes me feel so fine
And it's all there is
13 — 7 seconds, Youssou N'Dour | Dreamy references to a short period of time.
7 seconds away. Just as long as I stay. I'll be waiting.
14 — 100 Billion Stars, Lux | Something to relax to while you ponder insignificance.
15 — First Picture, Nikolaj Grandjean | First is the most memorable number.
I remember
The first picture
One million different shadows
Where we've been around the willows
16 — Millions of Millions, Music for a French Elevator | Very desirable. And I can't believe I transcribed the whole thing.
5.50 million dollars, 2.6775 and very desirable 8 million dollars 5.6 million and 2.4 million 3.4 million and 2.9 million 1.2 would've amounted to 4 million 1.2 million 19.4 million 6.6 million 5.275 million 1.2 million 3-and-a-half million dollars 6.453 million 8 million 5.050 million 1.4 million close to a million dollars 933.5 million 3.8 million 5 million dollars 2-and-a-half million 600 million dollars can you shut the door? 3-and-a-half million dollars 2.5 million .050 million 572,750 thousand 5.050 million 3.8 million 3 million 150 thousand 8 million 419.5 million
17 — Love Potion #9, The Searchers | I started kissing everythying in sight.
It smelled like turpentine, it looked like Indian ink
I held my nose, I closed my eyes, I took a drink.
18 — 93 Million Miles, Luan Santana feat. John Kip | A little sticky, a little sweet but it makes up for the fact that much of it is in Portuguese.
But the absence of the light is a necessary part.
news + thoughts
Oryza longistaminata genome cake
Data visualization should be informative and, where possible, tasty.
Stefan Reuscher from Bioscience and Biotechnology Center at Nagoya University celebrates a publication with a Circos cake.
The cake shows an overview of a de-novo assembled genome of a wild rice species Oryza longistaminata.
Optimal experimental design
Customize the experiment for the setting instead of adjusting the setting to fit a classical design.The presence of constraints in experiments, such as sample size restrictions, awkward blocking or disallowed treatment combinations may make using classical designs very difficult or impossible.
Optimal design is a powerful, general purpose alternative for high quality, statistically grounded designs under nonstandard conditions.
We discuss two types of optimal designs (D-optimal and I-optimal) and show how it can be applied to a scenario with sample size and blocking constraints.
Smucker, B., Krzywinski, M. & Altman, N. (2018) Points of significance: Optimal experimental design Nature Methods 15:599–600.
Background reading
Krzywinski, M., Altman, N. (2014) Points of significance: Two factor designs. Nature Methods 11:1187–1188.
Krzywinski, M. & Altman, N. (2014) Points of significance: Analysis of variance (ANOVA) and blocking. Nature Methods 11:699–700.
Krzywinski, M. & Altman, N. (2014) Points of significance: Designing comparative experiments. Nature Methods 11:597–598.
The Whole Earth Cataloguer
All the living things.An illustration of the Tree of Life, showing some of the key branches.
The tree is drawn as a DNA double helix, with bases colored to encode ribosomal RNA genes from various organisms on the tree.
All living things on earth descended from a single organism called LUCA (last universal common ancestor) and inherited LUCA’s genetic code for basic biological functions, such as translating DNA and creating proteins. Constant genetic mutations shuffled and altered this inheritance and added new genetic material—a process that created the diversity of life we see today. The “tree of life” organizes all organisms based on the extent of shuffling and alteration between them. The full tree has millions of branches and every living organism has its own place at one of the leaves in the tree. The simplified tree shown here depicts all three kingdoms of life: bacteria, archaebacteria and eukaryota. For some organisms a grey bar shows when they first appeared in the tree in millions of years (Ma). The double helix winding around the tree encodes highly conserved ribosomal RNA genes from various organisms.
Johnson, H.L. (2018) The Whole Earth Cataloguer, Sactown, Jun/Jul, p. 89
Why we can't give up this odd way of typing
All fingers report to home row.An article about keyboard layouts and the history and persistence of QWERTY.
My Carpalx keyboard optimization software is mentioned along with my World's Most Difficult Layout: TNWMLC. True typing hell.
McDonald, T. (2018) Why we can't give up this odd way of typing, BBC, 25 May 2018.
Molecular Case Studies Cover
The theme of the April issue of Molecular Case Studies is precision oncogenomics. We have three papers in the issue based on work done in our Personalized Oncogenomics Program (POG).
The covers of Molecular Case Studies typically show microscopy images, with some shown in a more abstract fashion. There's also the occasional Circos plot.
I've previously taken a more fine-art approach to cover design, such for those of Nature, Genome Research and Trends in Genetics. I've used microscopy images to create a cover for PNAS—the one that made biology look like astrophysics—and thought that this is kind of material I'd start with for the MCS cover.
Happy 2018 `\tau` Day—Art for everyone
