Here we are now at the middle of the fourth large part of this talk.
•
• get nowhere
• more quotes

very clickable

π day
·
ASCII
·
choices
·
clocks
·
color
·
covers
^{NEW}
·
deadly genomes
^{NEW}
·
debates
·
famous rat
·
gigapixel skies
^{NEW}
·
hitchens
·
huge voids
·
keyboards
·
languages
·
LOTRO
·
photography
·
questions
·
quotes
·
road trips
·
rockets
·
satire
·
sky constellations
^{NEW}
·
spam poetry
·
time
·
tripsum
·
type
·
unwords
·
words
·
writing
·
zaomm

visualization
**+** math

On March 14th celebrate `\pi` Day. Hug `\pi`—find a way to do it.

For those who favour `\tau=2\pi` will have to postpone celebrations until July 26th. That's what you get for thinking that `\pi` is wrong. I sympathize with this position and have `\tau` day art too!

If you're not into details, you may opt to party on July 22nd, which is `\pi` approximation day (`\pi` ≈ 22/7). It's 20% more accurate that the official `\pi` day!

Finally, if you believe that `\pi = 3`, you should read why `\pi` is not equal to 3.

2013 was the first year in which I made `\pi` day art. It was a year of dots and love.

René Hansen has created an interactive version of this year's posters! Why not go to the Feynman point directly!

All the posters are also available without the "`\pi` day 3 · 14" inscription.

`\pi_i` / grey 80% opacity

`\pi_i`/`\pi_{i+1}` 80% opacity

`\pi_i` / grey 80% opacity (equal neighbours connected)

`\pi_i` / `\pi_{i+1}` 80% opacity (equal neighbours connected)

— / `\pi_{i+1}` (equal neighbours connected, unconnected digits not shown)

`\pi_i` / `\pi_{i+1}` (equal neighbours connected with line width proportional to difference in neighbour digits `d in \{0,1,2\}`, unconnected digits not shown)

`\pi_i` / `\pi_{i+1}` (equal neighbours connected with line width proportional to difference in neighbour digits `d in \{0...5\}`, unconnected digits not shown)

`\pi` : — / red (equal neighbours connected, unconnected digits not shown)

`\phi` : — / white (equal neighbours connected, unconnected digits not shown)

`e` : — / grey (equal neighbours connected, unconnected digits not shown)

`\pi_i` / grey 80% opacity (equal neighbours connected)

`\pi_i` / `\pi_{i+1}` 80% opacity (equal neighbours connected)

`\pi_i` / grey 80% opacity (equal neighbours connected, unconnected digits not shown)

`\pi_i` / `\pi_{i+1}` 80% opacity (equal neighbours connected, unconnected digits not shown)

news
**+** thoughts

*If you sit on the sofa for your entire life, you’re running a higher risk of getting heart disease and cancer. —Alex Honnold, American rock climber*

In a follow-up to our Survival analysis — time-to-event data and censoring article, we look at how regression can be used to account for additional risk factors in survival analysis.

We explore accelerated failure time regression (AFTR) and the Cox Proportional Hazards model (Cox PH).

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Regression modeling of time-to-event data with censoring. *Nature Methods* **19**.

My 5-dimensional animation sets the visual stage for Max Cooper's *Ascent* from the album *Unspoken Words*. I have previously collaborated with Max on telling a story about infinity for his *Yearning for the Infinite* album.

I provide a walkthrough the video, describe the animation system I created to generate the frames, and show you all the keyframes

The video recently premiered on YouTube.

Renders of the full scene are available as NFTs.

*I am more than my genome and my genome is more than me.*

The MIT Museum reopened at its new location on 2nd October 2022. The new Gene Cultures exhibit featured my visualization of the human genome, which walks through the size and organization of the genome and some of the important structures.

My cover design on the 1 September 2022 Annals of Oncology issue shows 570 individual cases of difficult-to-treat cancers. Each case shows the number and type of actionable genomic alterations that were detected and the length of therapies that resulted from the analysis.

Pleasance E *et al.* Whole-genome and transcriptome analysis enhances precision cancer treatment options (2022) *Annals of Oncology* **33**:939–949.

Browse my gallery of cover designs.

*Love's the only engine of survival. —L. Cohen*

We begin a series on survival analysis in the context of its two key complications: skew (which calls for the use of probability distributions, such as the Weibull, that can accomodate skew) and censoring (required because we almost always fail to observe the event in question for all subjects).

We discuss right, left and interval censoring and how mishandling censoring can lead to bias and loss of sensitivity in tests that probe for differences in survival times.

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Survival analysis—time-to-event data and censoring. *Nature Methods* **19**:906–908.

*See How Scientists Put Together the Complete Human Genome.*

My graphic in Scientific American's Graphic Science section in the August 2022 issue shows the full history of the human genome assembly — from its humble shotgun beginnings to the gapless telomere-to-telomere assembly.

Read about the process and methods behind the creation of the graphic.

See all my Scientific American Graphic Science visualizations.

© 1999–2022 Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences Centre ⊂ BC Cancer Research Center ⊂ BC Cancer ⊂ PHSA