Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - contact me Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Lumondo Photography Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Art Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Hilbertonians - Creatures on the Hilbert CurveMartin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Day 2020 - Piku
Twenty — minutes — maybe — more.Naomichoose four wordsmore quotes

words: meaningful


Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca
2020 `\pi` day art and the piku


language + fiction

Dark Matter of the English Language—the unwords

Words are easy, like the wind;
Faithful friends are hard to find.
—William Shakespeare

These are maladies sampled from my list of about 883,500 English unwords.

Medical jargon has never been so opaque.

phobias

Don't feel like going to that party? It could be a conveniently timed attack of ictophobia or myconomascophobia.

—9—
abophobia
beophobia
cgyphobia
deophobia
epophobia
etaphobia
kanphobia
miophobia
—10—
alraphobia
beexphobia
bemophobia
cemophobia
cetophobia
dalophobia
degephobia
eccophobia
eedophobia
ficaphobia
galophobia
ganyphobia
helophobia
hilophobia
ictophobia
illyphobia
kelophobia
manophobia
menophobia
oxiophobia
perophobia
pisophobia
tegophobia
tenophobia
—11—
acctophobia
alonophobia
beonyphobia
beprephobia
caanophobia
cachophobia
deginphobia
deinephobia
ecquephobia
egycaphobia
geceophobia
geneophobia
inymophobia
iponephobia
kennophobia
lleiophobia
mactophobia
maenephobia
oeriophobia
optigphobia
paliophobia
parrophobia
reglophobia
scavophobia
starophobia
taloaphobia
teonaphobia
—12—
antotophobia
begatophobia
birroophobia
cabolophobia
canchophobia
dachoiphobia
debriophobia
elimiaphobia
enconophobia
fansoaphobia
fatenophobia
gedicophobia
gercomphobia
heralephobia
hyscrophobia
inchrophobia
ingonophobia
konetophobia
lamphophobia
lepinophobia
menoxiphobia
mezalophobia
neponophobia
oppetophobia
parkiophobia
preotaphobia
saconophobia
temphophobia
tilophphobia
uemanaphobia
vobitophobia
—13—
achythophobia
acteliophobia
becrosophobia
benoprophobia
cembaniphobia
chegenophobia
dambotophobia
denyarophobia
ecenytophobia
eerichophobia
fatenylphobia
galarsophobia
gannotophobia
hotoidophobia
iconopephobia
inbictophobia
kentylophobia
mallygophobia
manismyphobia
nonditophobia
oophalaphobia
ototarophobia
peltosaphobia
penconophobia
rechapophobia
rechorophobia
stimotophobia
stomosophobia
testanophobia
thidotophobia
vertulophobia
—14—
ancometophobia
antionsyphobia
cenctopaphobia
cheinonophobia
dempabiophobia
denolaryphobia
ecenytrophobia
edalycrophobia
gebrocomphobia
geoparyophobia
heegoscophobia
hindancophobia
ichicotyphobia
ideuschophobia
maromaniphobia
myolegrophobia
octonenophobia
onechotophobia
persectophobia
phetholyphobia

And here are some very long fears. I'm sure that one of these is the fear of long fears.

fires in the brain

Those thoughts you're having might not be yours. It could be talmatomania.

—7—
demania
gomania
namania
—8—
adomania
diomania
dipmania
fermania
giomania
maomania
peomania
thomania
—9—
adiamania
agnymania
benamania
brepmania
calemania
capumania
dipamania
disomania
egzomania
expomania
facomania
galamania
gamemania
hytomania
iglimania
ihyomania
ledimania
macemania
mallmania
najumania
pedamania
poelmania
susimania
tegomania
tigymania
uztimania
vicimania
—10—
agniomania
ampiamania
besmomania
ceedomania
centomania
deglimania
deykomania
eodaimania
fathemania
fertomania
galarmania
geolemania
inasamania
inorimania
leliomania
maaromania
mariomania
nedramania
nodiomania
plolomania
precamania
sereimania
tachymania
tattomania
viliomania
—11—
acculamania
antisumania
beedromania
beranimania
cemchomania
chetiomania
degonomania
demitemania
endonomania
eyleromania
flodiomania
gastdomania
gelyzymania
ingatomania
lamphomania
lamphymania
malatomania
maracamania
opostomania
perciomania
prathomania
teouromania
tieanomania
—12—
anchodymania
anchonomania
cirminomania
conchromania
degotrsmania
demminomania
encoctomania
eyotoxomania
gremgormania
mardisimania
mibeliomania
nenadiomania
parmulamania
pestriomania
talmatomania
thyminomania
wirgilamania
—13—
bepporanmania
berandromania
caconylymania
calebitomania
deborphomania
icepatromania
inferonomania
megazidomania
pecatisomania
peribacomania
seergenamania
stentosomania

stuff is definitely wrong

I'm not sure what's going on, but it might be an acute attack of ophalosis or that chronic icabulosis you've been struggling with.

—5—
cosis
gosis
iosis
mosis
—6—
axosis
buosis
byosis
ciosis
coosis
diosis
ecosis
egosis
feosis
geosis
idosis
irosis
keosis
meosis
moosis
pathyc
pathym
taosis
tiosis
—7—
algiang
algiate
bedosis
beeosis
calgias
cavosis
dehosis
didosis
edosist
eemosis
facosis
ferosis
galosis
gasosis
hedosis
hemosis
ichosis
idaosis
madosis
magosis
odiosis
odlosis
panosis
pecosis
roposis
saxosis
tacosis
talosis
vinosis
vorosis
—8—
acshosis
ademosis
bemposis
benosise
cactosis
caliosis
deagosis
demiosis
ecosises
egglosis
fattosis
fedlosis
gareosis
gariosis
harrosis
helposis
icerosis
ichnosis
leliosis
macosism
mactosis
nefkosis
neocosis
obbiosis
ocirosis
pathybic
pathymia
rechosis
tachosis
tendosis
—9—
acctrosis
acyclosis
balolosis
befalgian
cacacosis
cafulosis
danknosis
decarosis
echenosis
econeosis
falgnosis
fanulosis
gabarosis
galoxosis
heepathyl
hegriosis
icemosism
ichapathy
kelutosis
kenatosis
lamomosis
lebytosis
mabacosis
macalosis
nenylosis
nercrosis
odiosises
olohosism
panosises
partosism
quoetosis
regoosism
rhagnosis
saconosis
saumalgia
tacopathy
talthosis
undylosis
vhilalgia
vhinnosis
—10—
acaporosis
aceutiosis
bariakosis
becrotosis
cabesmosis
cachinosis
daiocrosis
daiphyosis
ecraniosis
eeminalgia
falogiosis
fedophosis
gaggonosis
gamancosis
heltonosis
heniflosis
icabulosis
icayulosis
kasphosise
kemoptosis
lephanosis
maccolosis
macosistic
namancosis
neocosises
oditopathy
omosinosis
palanrosis
panhidosis
rechoposis
rechosises
segiphosis
setactosis
tahradosis
taronosism
unodylosis
vhitatosis
vhoripathy
—11—
acdioenosis
actypyrosis
ballfrosise
becosistate
cacymalosis
caliphiosis
dalmatosise
dalomicosis
econeosises
ecrpharosis
facunolosis
fadiettosis
gacochrosis
gadersiosis
heleignosis
helipolosis
ibbiognosis
ichabolosis
jabimarosis
kedamirosis
kelodialgia
lelidalosis
macolobosis
macomycosis
nacocynosis
nectianosis
octoperosis
octorsposis
palevomosis
palygulosis
recocolosis
reglogyosis
sabrichosis
saconosises
teclagnosis
tellodrosis
untochosise
vurocylosis
—12—
abzibellosis
achythoposis
bakiomatosis
bedolignosis
cabolophosis
caconoacosis
dansepicosis
dantachrosis
ecchonylosis
ecctometosis
fansoaphosis
fentivorosis
gaelopyrosis
ganactomosis
hecthlinosis
hedophonosis
icaneoptosis
icepleitosis
karocalcosis
keloecatosis
lelemosisine
lelephotosis
macophagosis
maerozooosis
naniquinosis
nescroblosis
octorschosis
olethydrosis
pastiosising
pastiosismes
rechopatosis
rechopyrosis
segamethosis
seprorinosis
taronosismic
tedophirosis
venotormosis
vicypartosis
—13—
abobiolanosis
abrophyclosis
bailligirosis
beetheritosis
caccoparcosis
caconylycosis
decantophosis
decretharosis
ecccombulosis
ecyphenolosis
fansoecosises
feritoverosis
gaoduroniosis
gecivericosis
helatosteosis
heneotermosis
icenaronrosis
icernicycosis
kaumebedrosis
kelumbeenosis
lamphymbiosis
lelemosiseous
maelmicolosis
mafectermosis
neodylemnosis
noriotyphosis
octonepidosis
oepetymstosis
paccurognosis
paliascilosis
rerexomatosis
rimipathylene
stammomycosis
stolosibeosis
tadiotennosis
talhagunnosis
uneloplerosis
unmedunulosis
vhoriolecosis
vyrteobulosis
xlocrodynosis
—14—
acciritorrosis
accorbotolosis
bacocentamosis
becrotenicosis
caliphogniosis
calmicocenosis
danduocardosis
dantachromosis
ectinoliphosis
eggenopertosis
fematosishalle
fenhhaocamosis
galettonemosis
gaslogastrosis
hendimorphosis
henoptermeosis
icliotoidlosis
iddomethemosis
karapiapulosis
kichymarenosis
maccombuscosis
macophomacosis
nercrodidiosis
nondexicalosis
omestospidosis
ooracholosises
pacolimidrosis
pastinooctosis
qansinquirosis
rechanucenosis
saxinifactosis
secrotopolosis
tachomorphosis
tanadavicuosis
vericatorrosis
vhioductylosis

it's probably just age

Most of these are natural conditions associated with aging. I know mediatopathy definitely is and it always makes my bellotalgia flare up.

—7—
byalgia
—8—
alealgia
dymalgia
gelalgia
mydalgia
myzalgia
tinalgia
—9—
aditalgia
coomalgia
cyonalgia
diptalgia
drycalgia
egyralgia
enaralgia
inoralgia
irivalgia
mochalgia
myolalgia
saumalgia
sempalgia
vhilalgia
—10—
antoralgia
camoxalgia
ceavoalgia
detotalgia
dogosalgia
eeminalgia
goemoalgia
hotodalgia
ictetalgia
opennalgia
paniyalgia
pumonalgia
—11—
bellotalgia
bontaralgia
cicroyalgia
cinodyalgia
digratalgia
diodymalgia
eppersalgia
kelodialgia
progetalgia
pyrponalgia
surianalgia
—12—
artaramalgia
ceminonalgia
chempemalgia
degoestalgia
dehyzydalgia
fidetisalgia
genaroyalgia
geolaycalgia
manchomalgia
oorcastalgia
—13—
addigothalgia
conomethalgia
coronydralgia
doiocystalgia
epalanthalgia
keneopatalgia
manciscialgia
merycromalgia
olettrosalgia
oxosinchalgia
phiorhicalgia
proodustalgia

—7—
gepathy
mipathy
pupathy
—8—
dempathy
deopathy
geopathy
oxypathy
penpathy
—9—
antopathy
betopathy
bilypathy
cypopathy
detopathy
dipapathy
endopathy
finypathy
henopathy
ichapathy
inrepathy
manopathy
melopathy
notopathy
orcopathy
oviopathy
phiopathy
prempathy
tacopathy
tebopathy
—10—
acynopathy
aderipathy
biplopathy
cecropathy
cectopathy
deptopathy
deylopathy
egenopathy
eodyopathy
geneopathy
geolopathy
illyopathy
maliopathy
meddopathy
oditopathy
perropathy
phelopathy
teadopathy
vhoripathy
—11—
cherropathy
conchopathy
delphopathy
demylopathy
euchlopathy
helloopathy
omperopathy
phogiopathy
tyoptopathy
—12—
blatalopathy
cepigropathy
comyslopathy
ditheropathy
enceptopathy
mediatopathy
mompulopathy
orchypopathy
perrctopathy
prophropathy
—13—
chaldipopathy
chillitypathy
driboatopathy
miteligipathy

VIEW ALL

news + thoughts

The Outbreak Poems

Tue 24-03-2020

I'm writing poetry daily to put my feelings into words more often during the COVID-19 outbreak.

Panic can
wait
for tomorrow.
Regrets live
on
curves not tangents.
Small chances
are
never zero.
Month's last day
waits
for another
year.

Read the poems and learn what a piku is.

Deadly Genomes: Genome Structure and Size of Harmful Bacteria and Viruses

Tue 17-03-2020

A poster full of epidemiological worry and statistics. Now updated with the genome of SARS-CoV-2 and COVID-19 case statistics as of 3 March 2020.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Deadly Genomes: Genome Structure and Size of Harmful Bacteria and Viruses (zoom)

Bacterial and viral genomes of various diseases are drawn as paths with color encoding local GC content and curvature encoding local repeat content. Position of the genome encodes prevalence and mortality rate.

The deadly genomes collection has been updated with a posters of the genomes of SARS-CoV-2, the novel coronavirus that causes COVID-19.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Genomes of 56 SARS-CoV-2 coronaviruses that causes COVID-19.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Ball of 56 SARS-CoV-2 coronaviruses that causes COVID-19.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The first SARS-CoV-2 genome (MT019529) to be sequenced appears first on the poster.

Using Circos in Galaxy Australia Workshop

Wed 04-03-2020

A workshop in using the Circos Galaxy wrapper by Hiltemann and Rasche. Event organized by Australian Biocommons.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Using Circos in Galaxy Australia workshop. (zoom)

Download workshop slides.

Galaxy wrapper training materials, Saskia Hiltemann, Helena Rasche, 2020 Visualisation with Circos (Galaxy Training Materials).

Essence of Data Visualization in Bioinformatics Webinar

Thu 20-02-2020

My webinar on fundamental concepts in data visualization and visual communication of scientific data and concepts. Event organized by Australian Biocommons.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Essence of Data Visualization in Bioinformatics webinar. (zoom)

Download webinar slides.

Markov models — training and evaluation of hidden Markov models

Thu 20-02-2020

With one eye you are looking at the outside world, while with the other you are looking within yourself.
—Amedeo Modigliani

Following up with our Markov Chain column and Hidden Markov model column, this month we look at how Markov models are trained using the example of biased coin.

We introduce the concepts of forward and backward probabilities and explicitly show how they are calculated in the training process using the Baum-Welch algorithm. We also discuss the value of ensemble models and the use of pseudocounts for cases where rare observations are expected but not necessarily seen.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Markov models — training and evaluation of hidden Markov models. (read)

Grewal, J., Krzywinski, M. & Altman, N. (2019) Points of significance: Markov models — training and evaluation of hidden Markov models. Nature Methods 17:121–122.

Background reading

Altman, N. & Krzywinski, M. (2019) Points of significance: Hidden Markov models. Nature Methods 16:795–796.

Altman, N. & Krzywinski, M. (2019) Points of significance: Markov Chains. Nature Methods 16:663–664.

Genome Sciences Center 20th Anniversary Clothing, Music, Drinks and Art

Tue 28-01-2020

Science. Timeliness. Respect.

Read about the design of the clothing, music, drinks and art for the Genome Sciences Center 20th Anniversary Celebration, held on 15 November 2019.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Luke and Mayia wearing limited edition volunteer t-shirts. The pattern reproduces the human genome with chromosomes as spirals. (zoom)

As part of the celebration and with the help of our engineering team, we framed 48 flow cells from the lab.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Precisely engineered frame mounts of flow cells used to sequence genomes in our laboratory. (zoom)

Each flow cell was accompanied by an interpretive plaque explaining the technology behind the flow cell and the sample information and sequence content.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The plaque at the back of one of the framed Illumina flow cell. This one has sequence from a patient's lymph node diagnosed with Burkitt's lymphoma. (zoom)