Martin Krzywinski / Genome Sciences Center / Martin Krzywinski / Genome Sciences Center / - contact me Martin Krzywinski / Genome Sciences Center / on Twitter Martin Krzywinski / Genome Sciences Center / - Lumondo Photography Martin Krzywinski / Genome Sciences Center / - Pi Art Martin Krzywinski / Genome Sciences Center / - Hilbertonians - Creatures on the Hilbert Curve
Mad about you, orchestrally.Hooverphonicfeel the vibe, feel the terror, feel the painmore quotes

quotes: exciting

EMBO Practical Course: Bioinformatics and Genome Analysis, 5–17 June 2017.

art + literature

daily quotation server archives

In the late 90’s I started (a good decade for starts) a daily quotation server project at The domain is now defunct—some pages are partially viewable at the Way Back Machine.

Below is the list of quotes I had collected by the end of the life of the project. Most are about love—duh—and a few are jolly jests from funny trenches. You know, that place where mustard gas makes your eyes water.

The quotes weren’t scraped from quote archives—each is meaningful and hand-picked.

the quote archive

And now for full list of 1,600 other things worth reading. Such as everything Dorothy Parker has written and ... yes, even the Pinky and Brain quotes, which are a special kind of special.

Quote collections about love, heart, desire, life, death, god, mind, science.

Feeling lucky? Read 10 random quotes. Well, will you, punk?

A subset of random quotes

A little inaccuracy sometimes saves a ton of explanation.
H.H. Munro
When you’re away, I’m restless, lonely,
Wretched, bored, dejected; only
Here’s the rub, my darling dear,
I feel the same when you’re here.
Samuel Hoffenstein
The bed of the well,
The end of the line,
The dismay in the face,
It’s a loss, it’s a find.
Antonio Carlos Jobim
Water of March
They are not long, the weeping and the laughter,
Love and desire and hate:
I think they have no portion in us after
We pass the gate.
Ernest Dowson
Vitae Summa Brevis Spem Nos Vetat Incohare Longham
Love is the delightful interval between meeting
a beautiful girl and discovering that she looks
like a haddock.
John Barrymore
A man can be happy with any woman as long as he does not love her.
Oscar Wilde
Faith: not wanting to know what is true.
Friedrich Nietzsche
The measure of our intellectual capacity is the capacity to feel less and less satisfied with our answers to better and better problems.
C.W. Churchman
A Mathematician’s Miscellany by J.E. Littlewood [quoted]
Don’t wait for the last judgment. It takes place every day.
Albert Camus
Gravity cannot be held responsible for people falling in love.
Albert Einstein

news + thoughts

Tabular Data

Tue 11-04-2017
Tabulating the number of objects in categories of interest dates back to the earliest records of commerce and population censuses.

After 30 columns, this is our first one without a single figure. Sometimes a table is all you need.

In this column, we discuss nominal categorical data, in which data points are assigned to categories in which there is no implied order. We introduce one-way and two-way tables and the `\chi^2` and Fisher's exact tests.

Altman, N. & Krzywinski, M. (2017) Points of Significance: Tabular data. Nature Methods 14:329–330.

...more about the Points of Significance column

Happy 2017 `\pi` Day—Star Charts, Creatures Once Living and a Poem

Tue 14-03-2017

on a brim of echo,

capsized chamber
drawn into our constellation, and cooling.
—Paolo Marcazzan

Celebrate `\pi` Day (March 14th) with star chart of the digits. The charts draw 40,000 stars generated from the first 12 million digits.

Martin Krzywinski @MKrzywinski
12,000,000 digits of `\pi` interpreted as a star catalogue. (details)

The 80 constellations are extinct animals and plants. Here you'll find old friends and new stories. Read about how Desmodus is always trying to escape or how Megalodon terrorizes the poor Tecopa! Most constellations have a story.

Martin Krzywinski @MKrzywinski
Find friends and stories among the 80 constellations of extinct animals and plants. Oh look, a Dodo guardings his eggs! (details)

This year I collaborate with Paolo Marcazzan, a Canadian poet, who contributes a poem, Of Black Body, about space and things we might find and lose there.

Check out art from previous years: 2013 `\pi` Day and 2014 `\pi` Day, 2015 `\pi` Day and and 2016 `\pi` Day.

Data in New Dimensions: convergence of art, genomics and bioinformatics

Tue 07-03-2017

Art is science in love.
— E.F. Weisslitz

A behind-the-scenes look at the making of our stereoscopic images which were at display at the AGBT 2017 Conference in February. The art is a creative collaboration with Becton Dickinson and The Linus Group.

Its creation began with the concept of differences and my writeup of the creative and design process focuses on storytelling and how concept of differences is incorporated into the art.

Oh, and this might be a good time to pick up some red-blue 3D glasses.

BD Genomics 3D art exhibit - AGBT 2017 / Martin Krzywinski @MKrzywinski
A stereoscopic image and its interpretive panel of single-cell transcriptomes of blood cells: diseased versus healthy control.

Interpreting P values

Thu 02-03-2017
A P value measures a sample’s compatibility with a hypothesis, not the truth of the hypothesis.

This month we continue our discussion about `P` values and focus on the fact that `P` value is a probability statement about the observed sample in the context of a hypothesis, not about the hypothesis being tested.

Martin Krzywinski @MKrzywinski
Nature Methods Points of Significance column: Interpreting P values. (read)

Given that we are always interested in making inferences about hypotheses, we discuss how `P` values can be used to do this by way of the Benjamin-Berger bound, `\bar{B}` on the Bayes factor, `B`.

Heuristics such as these are valuable in helping to interpret `P` values, though we stress that `P` values vary from sample to sample and hence many sources of evidence need to be examined before drawing scientific conclusions.

Altman, N. & Krzywinski, M. (2017) Points of Significance: Interpreting P values. Nature Methods 14:213–214.

Background reading

Krzywinski, M. & Altman, N. (2017) Points of significance: P values and the search for significance. Nature Methods 14:3–4.

Krzywinski, M. & Altman, N. (2013) Points of significance: Significance, P values and t–tests. Nature Methods 10:1041–1042.

...more about the Points of Significance column

Snellen Charts—Typography to Really Look at

Sat 18-02-2017

Another collection of typographical posters. These ones really ask you to look.

Martin Krzywinski @MKrzywinski
Snellen charts designed using physical constants, Braille and elemental abundances in the universe and human body.

The charts show a variety of interesting symbols and operators found in science and math. The design is in the style of a Snellen chart and typset with the Rockwell font.