As a white candle
In a holy place,
So is the beauty
Of an aged faced.
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A grand challenge
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The Earth BioGenome Project (EBP) is a moonshot for biology, aims to sequence, catalog and characterize the genomes of all of Earthâs eukaryotic biodiversity over a period of ten years. The articles in this special issue of PNAS explore aspects of the project including a review of progress, descriptions of major scientific goals, exemplar projects, examinations of ethical, legal, and social issues, and applications of biodiversity genomics.
▲ 1,709 quotes and all is well.
The archive contains 1,709 quotes. From Dorothy Parker to Pinky and Brain, you're sure to find something special.
There are quote collections about love, heart, desire, life, death, god, mind, science.
Feeling lucky? Read 10 random quotes. Well, will you, punk?
A subset of random quotes
58
The Old Woman
403
To change one’s life:
1. Start immediately
2. Do it flamboyantly
3. No exceptions
1. Start immediately
2. Do it flamboyantly
3. No exceptions
589
The path of excess leads to the tower of wisdom.
591
If you believe in the light, it’s because of obscurity.
If you believe in happiness it’s because of unhappiness.
If you believe in God, then you have to believe in the Devil.
If you believe in happiness it’s because of unhappiness.
If you believe in God, then you have to believe in the Devil.
Church of Notre Dame, Paris
677
Her eyes as stars of twilight fair;
Like twilight’s, too, her dusky hair;
Like twilight’s, too, her dusky hair;
She Was a Phantom of Delight
747
No man was ever yet a great poet, without
being at the same time a profound philosopher.
being at the same time a profound philosopher.
1391
Anything that is too stupid to be spoken is sung.
1433
You can’t say civilization doesn’t advance. In every war they kill you in a new way.
1551
Mathematics is not a careful march down a well-cleared highway, but a journey into a strange wilderness, where the explorers often get lost. Rigour should be a signal to the historian that the maps have been made, and the real explorers have gone elsewhere.
Mathematics and History, Mathematical Intelligencer, v. 4, no. 4
1672
Life is short. But death is very, very long.
Quicksand
news
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Convolutional neural networks
Nature uses only the longest threads to weave her patterns, so that each small piece of her fabric reveals the organization of the entire tapestry. â Richard Feynman
Following up on our Neural network primer column, this month we explore a different kind of network architecture: a convolutional network.
The convolutional network replaces the hidden layer of a fully connected network (FCN) with one or more filters (a kind of neuron that looks at the input within a narrow window).
▲ Nature Methods Points of Significance column: Convolutional neural networks.
(read)
Even through convolutional networks have far fewer neurons that an FCN, they can perform substantially better for certain kinds of problems, such as sequence motif detection.
Derry, A., Krzywinski, M & Altman, N. (2023) Points of significance: Convolutional neural networks. Nature Methods 20:.
Background reading
Derry, A., Krzywinski, M. & Altman, N. (2023) Points of significance: Neural network primer. Nature Methods 20:165â167.
Lever, J., Krzywinski, M. & Altman, N. (2016) Points of significance: Logistic regression. Nature Methods 13:541â542.
Neural network primer
Nature is often hidden, sometimes overcome, seldom extinguished. âFrancis Bacon
In the first of a series of columns about neural networks, we introduce them with an intuitive approach that draws from our discussion about logistic regression.
▲ Nature Methods Points of Significance column: Neural network primer.
(read)
Simple neural networks are just a chain of linear regressions. And, although neural network models can get very complicated, their essence can be understood in terms of relatively basic principles.
We show how neural network components (neurons) can be arranged in the network and discuss the ideas of hidden layers. Using a simple data set we show how even a 3-neuron neural network can already model relatively complicated data patterns.
Derry, A., Krzywinski, M & Altman, N. (2023) Points of significance: Neural network primer. Nature Methods 20:165–167.
Background reading
Lever, J., Krzywinski, M. & Altman, N. (2016) Points of significance: Logistic regression. Nature Methods 13:541â542.
Cell Genomics cover
Our cover on the 11 January 2023 Cell Genomics issue depicts the process of determining the parent-of-origin using differential methylation of alleles at imprinted regions (iDMRs) is imagined as a circuit.
Designed in collaboration with with Carlos Urzua.
▲ Our Cell Genomics cover depicts parent-of-origin assignment as a circuit (volume 3, issue 1, 11 January 2023).
(more)
Akbari, V. et al. Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq (2023) Cell Genomics 3(1).
Browse my gallery of cover designs.
▲ A catalogue of my journal and magazine cover designs.
(more)
Science Advances cover
My cover design on the 6 January 2023 Science Advances issue depicts DNA sequencing read translation in high-dimensional space. The image showss 672 bases of sequencing barcodes generated by three different single-cell RNA sequencing platforms were encoded as oriented triangles on the faces of three 7-dimensional cubes.
More details about the design.
▲ My Science Advances cover that encodes sequence onto hypercubes (volume 9, issue 1, 6 January 2023).
(more)
Kijima, Y. et al. A universal sequencing read interpreter (2023) Science Advances 9.
Browse my gallery of cover designs.
▲ A catalogue of my journal and magazine cover designs.
(more)
Regression modeling of time-to-event data with censoring
If you sit on the sofa for your entire life, youâre running a higher risk of getting heart disease and cancer. âAlex Honnold, American rock climber
In a follow-up to our Survival analysis — time-to-event data and censoring article, we look at how regression can be used to account for additional risk factors in survival analysis.
We explore accelerated failure time regression (AFTR) and the Cox Proportional Hazards model (Cox PH).
▲ Nature Methods Points of Significance column: Regression modeling of time-to-event data with censoring.
(read)
Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Regression modeling of time-to-event data with censoring. Nature Methods 19:1513–1515.
© 1999–2023 Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences Centre ⊂ BC Cancer Research Center ⊂ BC Cancer ⊂ PHSA