Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - contact me Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Lumondo Photography Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Pi Art Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Hilbertonians - Creatures on the Hilbert Curve
Trance opera—Spente le Stellebe dramaticmore quotes

quotes: exciting


EMBO Practical Course: Bioinformatics and Genome Analysis, 5–17 June 2017.


art + literature

daily quotation server archives

In the late 90’s I started (a good decade for starts) a daily quotation server project at www.quoteserver.ca. The domain is now defunct—some pages are partially viewable at the Way Back Machine.

Below is the list of quotes I had collected by the end of the life of the project. Most are about love—duh—and a few are jolly jests from funny trenches. You know, that place where mustard gas makes your eyes water.

The quotes weren’t scraped from quote archives—each is meaningful and hand-picked.

the quote archive

And now for full list of 1,600 other things worth reading. Such as everything Dorothy Parker has written and ... yes, even the Pinky and Brain quotes, which are a special kind of special.

Quote collections about love, heart, desire, life, death, god, mind, science.

Feeling lucky? Read 10 random quotes. Well, will you, punk?

Quotes about god

13
Take not God’s name in vain: select a time when it will have effect.
Ambrose Bierce
48
I love thee with the love I seemed to lose
With my lost saints,—I love thee with the breath
Smiles, tears, of all my life!—and, if God choose,
I shall but love thee better after death.
Elizabeth Barrett Browning
Sonnets from the Portuguese
104
Poems are made by fools like me,
But only God can make a tree.
Joyce Kilmer
Trees
117
All are but parts of one stupendous whole,
Whose body Nature is, and God the soul.
Alexander Pope
Essay on Man, Epistle i. 267.
243
Conceit is God’s gift to little men.
298
Poems are made by fools like me,
But only God can make a tree.
Joyce Kilmer
Trees
370
Men rarely (if ever) manage to dream up a god superior to themselves. Most gods have the manners and morals of a spoiled child.
Lazarus Long
Time Enough for Love
414
And, while with silent, lifting mind I’ve trod
The high untrespassed sanctity of space,
Put out my hand, and touched the face of God.
John Gillespie Magee, Jr.
452
God must love stupid people, He made so many of them.
457
If it turns out that there is a God, I don’t think that he’s evil. But the worst that you can say about him is that basically he’s an underachiever.
Woody Allen
556
% ar m God
ar: God does not exist
561
God made the integers; all else is the work of Man.
Kronecker
591
If you believe in the light, it’s because of obscurity.
If you believe in happiness it’s because of unhappiness.
If you believe in God, then you have to believe in the Devil.
Father X
Church of Notre Dame, Paris
609
O God, if there be a God, save my soul, if I have a soul!
611
See the happy moron,
He doesn’t give a damn.
I wish I were a moron.
My God! Perhaps I am!
706
An Apology for the Devil: It must be remembered that
we have only heard one side of the case. God has written
all the books.
Samuel Butler
Note Books
741
And almost every one when age,
Disease, or sorrows strike him,
Inclines to think there is a God,
Or something very like Him.
Arthur Hugh Clough
Dipsychus, sc. vi
783
So nigh is grandeur to our dust,
So near is God to man,
When Duty whispers low, Thou must,
The youth replies, I can.
Ralph Waldo Emerson
Voluntaries, iii
957
Gott ist tot: aber so wie die Art der Menschen ist,
wird es vielleicht noch jahrtausendlang Hohlen geben,
in denen man seinen Schatten zeigt.
[God is dead: but considering the state the species Man
is in, there will perhaps be caves, for ages yet, in which
his shadow will be shown.]
Friedrich Nietzsche
Ecce Homo
1082
O God! methinks it were a happy life,
To be no better than a homely swain;
To sit upon a hill, as I do now,
To carve out dials, quaintly, point by point,
Thereby to see the minutes how they run,
How many make the hour full complete;
How many hours bring about the day;
How many days will finish up the year;
How many years a mortal man may live.
William Shakespeare
Henry VII, Part III, II.v.21
1213
I loved you without hope, a mute offender;
What jealous pangs, what shy despairs I knew!
A love as deep as this, as true, as tender,
God grant another may yet offer you.
Alexander Pushkin
I Loved You Once
1218
I have heard the song of the blossoms and the old chant of the sea,
And seen strange lands from under the arched white sails of ships;
But the loveliest things of beauty God ever has showed to me,
Are her voice, and her hair, and eyes, and the dear red curve of her lips.
John Masefield
Beauty
1284
And this, O love, my pitiable plight
Whenever from my circling arms you stray;
This little world of mine has lost its light....
I hope to God, my dear, that you can say
The same to me.
Dorothy Parker
Rondeau Redouble
1333
How can I believe in God when just last week I got
my tongue caught in the roller of an electric typewriter?
Woody Allen
1334
Man is a god in ruins.
Ralph Waldo Emerson
1386
God made everything out of nothing, but the nothingness
shows through.
Paul Valery
1402
Which is it, is man one of God’s blunders or is
God one of man’s?
Friedrich Nietzsche
1416
Thank God men cannot as yet fly and lay waste the
sky as well as the earth!
Henry David Thoreau
1477
Nothing but blackness above
And nothing that moves but the cars...
God, if you wish for our love,
Fling us a handful of stars!
Louis Untermeyer
Caliban in the Coal Mines
1526
God is the immemorial refuge of the incompetent, the helpless, the miserable. They find not only sanctuary in His arms, but also a kind of superiority, soothing to their macerated egos; He will set them above their betters.
H.L. Mencken
1534
If the average man is made in God’s image, then a man such as Beethoven or Aristotle is plainly superior to God, and so God may be jealous of him, and eager to see his superiority perish with his bodily frame. All animal breeders know how difficult it is to maintain a fine strain. The universe seems to be in a conspiracy to encourage the endless reproduction of peasants and Socialists, but a subtle and mysterious opposition stands eternally against the reproduction of philosophers.
H.L. Mencken
In Defense of Women
1602
We turn toward God only to obtain the impossible.
Albert Camus
VIEW ALL

news + thoughts

Classification and regression trees

Fri 28-07-2017
Decision trees are a powerful but simple prediction method.

Decision trees classify data by splitting it along the predictor axes into partitions with homogeneous values of the dependent variable. Unlike logistic or linear regression, CART does not develop a prediction equation. Instead, data are predicted by a series of binary decisions based on the boundaries of the splits. Decision trees are very effective and the resulting rules are readily interpreted.

Trees can be built using different metrics that measure how well the splits divide up the data classes: Gini index, entropy or misclassification error.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Classification and decision trees. (read)

When the predictor variable is quantitative and not categorical, regression trees are used. Here, the data are still split but now the predictor variable is estimated by the average within the split boundaries. Tree growth can be controlled using the complexity parameter, a measure of the relative improvement of each new split.

Individual trees can be very sensitive to minor changes in the data and even better prediction can be achieved by exploiting this variability. Using ensemble methods, we can grow multiple trees from the same data.

Krzywinski, M. & Altman, N. (2017) Points of Significance: Classification and regression trees. Nature Methods 14:757–758.

Background reading

Lever, J., Krzywinski, M. & Altman, N. (2016) Points of Significance: Logistic regression. Nature Methods 13:541-542.

Altman, N. & Krzywinski, M. (2015) Points of Significance: Multiple Linear Regression Nature Methods 12:1103-1104.

Lever, J., Krzywinski, M. & Altman, N. (2016) Points of Significance: Classifier evaluation. Nature Methods 13:603-604.

Lever, J., Krzywinski, M. & Altman, N. (2016) Points of Significance: Model Selection and Overfitting. Nature Methods 13:703-704.

Lever, J., Krzywinski, M. & Altman, N. (2016) Points of Significance: Regularization. Nature Methods 13:803-804.

...more about the Points of Significance column

Personal Oncogenomics Program 5 Year Anniversary Art

Wed 26-07-2017

The artwork was created in collaboration with my colleagues at the Genome Sciences Center to celebrate the 5 year anniversary of the Personalized Oncogenomics Program (POG).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
5 Years of Personalized Oncogenomics Program at Canada's Michael Smith Genome Sciences Centre. The poster shows 545 cancer cases. (left) Cases ordered chronologically by case number. (right) Cases grouped by diagnosis (tissue type) and then by similarity within group.

The Personal Oncogenomics Program (POG) is a collaborative research study including many BC Cancer Agency oncologists, pathologists and other clinicians along with Canada's Michael Smith Genome Sciences Centre with support from BC Cancer Foundation.

The aim of the program is to sequence, analyze and compare the genome of each patient's cancer—the entire DNA and RNA inside tumor cells— in order to understand what is enabling it to identify less toxic and more effective treatment options.

Principal component analysis

Thu 06-07-2017
PCA helps you interpret your data, but it will not always find the important patterns.

Principal component analysis (PCA) simplifies the complexity in high-dimensional data by reducing its number of dimensions.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Principal component analysis. (read)

To retain trend and patterns in the reduced representation, PCA finds linear combinations of canonical dimensions that maximize the variance of the projection of the data.

PCA is helpful in visualizing high-dimensional data and scatter plots based on 2-dimensional PCA can reveal clusters.

Altman, N. & Krzywinski, M. (2017) Points of Significance: Principal component analysis. Nature Methods 14:641–642.

Background reading

Altman, N. & Krzywinski, M. (2017) Points of Significance: Clustering. Nature Methods 14:545–546.

...more about the Points of Significance column

`k` index: a weightlighting and Crossfit performance measure

Wed 07-06-2017

Similar to the `h` index in publishing, the `k` index is a measure of fitness performance.

To achieve a `k` index for a movement you must perform `k` unbroken reps at `k`% 1RM.

The expected value for the `k` index is probably somewhere in the range of `k = 26` to `k=35`, with higher values progressively more difficult to achieve.

In my `k` index introduction article I provide detailed explanation, rep scheme table and WOD example.

Dark Matter of the English Language—the unwords

Wed 07-06-2017

I've applied the char-rnn recurrent neural network to generate new words, names of drugs and countries.

The effect is intriguing and facetious—yes, those are real words.

But these are not: necronology, abobionalism, gabdologist, and nonerify.

These places only exist in the mind: Conchar and Pobacia, Hzuuland, New Kain, Rabibus and Megee Islands, Sentip and Sitina, Sinistan and Urzenia.

And these are the imaginary afflictions of the imagination: ictophobia, myconomascophobia, and talmatomania.

And these, of the body: ophalosis, icabulosis, mediatopathy and bellotalgia.

Want to name your baby? Or someone else's baby? Try Ginavietta Xilly Anganelel or Ferandulde Hommanloco Kictortick.

When taking new therapeutics, never mix salivac and labromine. And don't forget that abadarone is best taken on an empty stomach.

And nothing increases the chance of getting that grant funded than proposing the study of a new –ome! We really need someone to looking into the femome and manome.