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The Nature Methods Points of Significance column is an educational resource to all authors that provides practical suggestions about best practices in statistical analysis and reporting.
Martin Krzywinski @MKrzywinski
1,708 quotes and all is well.

The archive contains 1,708 quotes. From Dorothy Parker to Pinky and Brain, you're sure to find something special.

There are quote collections about love, heart, desire, life, death, god, mind, science.

Feeling lucky? Read 10 random quotes. Well, will you, punk?

All quotes about death

Little fly, thy summer’s play
My careless hand hath brushed away.
Am not I a fly like thee,
Or art not thou a man like me.
For I dance, and drink, and sing
Till some blind hand doth brush my wing.
If that is life, and strength, and breath
And the word of thought is death
Then am I a happy fly?
If I live, or if I die.
William Blake
Sleep is a death, O make me try
By sleeping, what it is to die,
And as gently lay my head
On my grave, as now my bed.
Sir Thomas Browne
Religio Medici, part II
I love thee with the love I seemed to lose
With my lost saints,—I love thee with the breath
Smiles, tears, of all my life!—and, if God choose,
I shall but love thee better after death.
Elizabeth Barrett Browning
Sonnets from the Portuguese
To-morrow, and to-morrow, and to-morrow,
Creeps in this petty pace from day to day
To the last syllable of recorded time,
And all our yesterdays have lighted fools
The way to dusty death.
Out, out, brief candle!
Life’s but a walking shadow, a poor player
That struts and frets his hour upon the stage
And then is heard no more: it is a tale
Told by an idiot, full of sound and fury,
Signifying nothing.
William Shakespeare
Macbeth, V. i. 19.
Half a league, half a league,
Half a league onward,
All in the valley of Death
Rode the six hundred.
Alfred Tennyson
Charge of the Light Brigade
Sleep—Death without dying—living, but not life.
Edwin Arnold
Death is sometimes a punishment, sometimes a gift;
To many it has come as a favor.
The prince who kept the world in awe,
The judge whose dictate fix’d the law;
The rich, the poor, the great, the small,
Are levelled; death confounds ’em all.
Because I could not stop for Death,
He kindly stopped for me,
The carriage held but just ourselves
And Immortality.
Emily Dickinson
Life without a friend is like death without a witness.
Death comes with a crawl, or comes with a pounce,
And whether he’s slow or spry,
It isn’t the fact that you’re dead that counts,
But only, how did you die?
Edmund Vance Cooke
How Did You Die?
Windows NT crashed.
I am the Blue Screen of Death.
No one hears your screams.
A Haiku computer error message.
Three things are certain:
Death, taxes and lost data.
Guess which has occurred.
A Haiku computer error message.
Death is nature’s way of telling you to slow down.
Don’t be afraid of death so much as an inadequate life.
Bertolt Brecht
He is one of those people who would be enormously improved by death.
H.H. Munro
Those who fear death most are those who enjoy life least.
Marriage is the death of hope.
Woody Allen
At six o’clock we cleaned our cells,
At seven all was still,
But the sough and swing of a mighty wing
The prison seemed to fill,
For the Lord of Death with icy breath
Had entered in to kill.
Oscar Wilde
The Ballad of Reading Gaol
The smallest sprout shows there is really no death.
And if ever there was it led forward life, and does not
wait at the end to arrest it.
Walt Whitman
Song of Myself
I do not believe that any man fears to be dead, but only the stroke of death.
Francis Bacon
An Essay on Death
All tragedies are finish’d by a death,
All comedies are ended by a marriage.
Lord Byron
Don Juan, c.iii, st. 9
Vivre est un maladie dont le sommeil nous soulage toutes les 16 heures. C’est un pallatif. La mort est le remede.
[Living is an illness to which sleep provides relief every sixteen hours. It’s a palliative.
The remedy is death.]
Nicolas-Sebastien Chamfort
Maximes et Pensees, ch. 2
Death hath so many doors to let out life.
John Fletcher
The Custom of the Country, II.ii
Then, with no throbs of fiery pain,
No cold gradations of decay,
Death broke at once the vital chain,
And freed his soul the nearest way.
Samuel Johnson
Of Gray’s Odes
O death! I know it—’tis my famulus—
Thus turns to naught my fairest bliss!
That visions in abundance such as this
Must be disturbed by that dry prowler thus!
Johann Wolfgang von Goethe
For the crown of our life as it closes
Is darkness, the fruit there of dust;
No thorns go as deep as the rose’s,
And love is more cruel than lust.
Time turns the old days to derision,
Our loves into corpses or wives;
And marriage and death and division
Make barren our lives.
Algernon Charles Swinburne
Though they go mad they shall be sane.
Though they sink through the sea, they shall rise again.
Though lovers be lost, love shall not,
And death shall have no dominion.
Dylan Thomas
My life is light, waiting for the death wind,
Like a feather on the back of my hand.
T.S. Eliot
Death be not proud, though some have called thee
Mighty and dreadful, for, thou art not so,
For, those, whom thou think’st, thou dost overthrow,
Die not, poor death, nor yet canst thou kill me.
John Donne
Holy Sonnets X
Don’t strew me with roses after I’m dead.
When Death claims the light of my brow
No flowers of life will cheer me: instead
You may give me my roses now!
Thomas F. Healey
Suffer me to take your hand.
Suffer me to cherish you
Till the dawn is in the sky.
Whether I be false or true,
Death comes in a day or two.
Edna St. Vincent Millay
Show me a love was done and through,
Tell me a kiss escaped its debt!
Son, to your death you’ll pay your due—
Women and elephants never forget.
Dorothy Parker
Ballade of Unfortunate Mammals
Oh, it is sure as it is sad
That any lad is every lad,
And what’s a girl, to dare impore
Her dear be hers forevermore?
Though he be tried and he be bold,
And swearing death should he be cold,
He’ll run the path the others went....
But you, my sweet, are different.
Dorothy Parker
In every parting there is an image of death.
George Eliot
For the Angel of Death spread his wings on the blast,
And breathed in the face of the foe as he pass’d;
And the eyes of the sleepers wax’d deadly and chill,
And their hearts but once heaved, and for ever grew still!
Lord Byron
The Destruction of Sennacherib
To die, to sleep—
To sleep, perchance to dream, ay there’s the rub,
For in that sleep of death what dreams may come
When we have shuffled off this mortal coil,
Must give us pause; there’s the respect
That makes calamity of so long life.
William Shakespeare
The harder the conflict, the more glorious the triumph. What we obtain too cheap, we esteem too lightly; it is dearness only that gives everything its value. I love the man that can smile in trouble, that can gather strength from distress and grow brave by reflection. ’Tis the business of little minds to shrink; but he whose heart is firm, and whose conscience approves his conduct, will pursue his principles unto death.
Thomas Paine
I do not want to believe that death is the gateway to another life. For me, it is a closed door. I do not say it is a step we must all take, but that it is a horrible and dirty adventure.
Albert Camus
Life is short. But death is very, very long.
Henning Mankell
news + thoughts

Regression modeling of time-to-event data with censoring

Mon 21-11-2022

If you sit on the sofa for your entire life, you’re running a higher risk of getting heart disease and cancer. —Alex Honnold, American rock climber

In a follow-up to our Survival analysis — time-to-event data and censoring article, we look at how regression can be used to account for additional risk factors in survival analysis.

We explore accelerated failure time regression (AFTR) and the Cox Proportional Hazards model (Cox PH).

Martin Krzywinski @MKrzywinski
Nature Methods Points of Significance column: Regression modeling of time-to-event data with censoring. (read)

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Regression modeling of time-to-event data with censoring. Nature Methods 19.

Music video for Max Cooper's Ascent

Tue 25-10-2022

My 5-dimensional animation sets the visual stage for Max Cooper's Ascent from the album Unspoken Words. I have previously collaborated with Max on telling a story about infinity for his Yearning for the Infinite album.

I provide a walkthrough the video, describe the animation system I created to generate the frames, and show you all the keyframes

Martin Krzywinski @MKrzywinski
Frame 4897 from the music video of Max Cooper's Asent.

The video recently premiered on YouTube.

Renders of the full scene are available as NFTs.

Gene Cultures exhibit — art at the MIT Museum

Tue 25-10-2022

I am more than my genome and my genome is more than me.

The MIT Museum reopened at its new location on 2nd October 2022. The new Gene Cultures exhibit featured my visualization of the human genome, which walks through the size and organization of the genome and some of the important structures.

Martin Krzywinski @MKrzywinski
My art at the MIT Museum Gene Cultures exhibit tells shows the scale and structure of the human genome. Pay no attention to the pink chicken.

Annals of Oncology cover

Wed 14-09-2022

My cover design on the 1 September 2022 Annals of Oncology issue shows 570 individual cases of difficult-to-treat cancers. Each case shows the number and type of actionable genomic alterations that were detected and the length of therapies that resulted from the analysis.

Martin Krzywinski @MKrzywinski
An organic arrangement of 570 individual cases of difficult-to-treat cancers showing genomic changes and therapies. Apperas on Annals of Oncology cover (volume 33, issue 9, 1 September 2022).

Pleasance E et al. Whole-genome and transcriptome analysis enhances precision cancer treatment options (2022) Annals of Oncology 33:939–949.

Martin Krzywinski @MKrzywinski
My Annals of Oncology 570 cancer cohort cover (volume 33, issue 9, 1 September 2022). (more)

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski
A catalogue of my journal and magazine cover designs. (more)

Survival analysis—time-to-event data and censoring

Fri 05-08-2022

Love's the only engine of survival. —L. Cohen

We begin a series on survival analysis in the context of its two key complications: skew (which calls for the use of probability distributions, such as the Weibull, that can accomodate skew) and censoring (required because we almost always fail to observe the event in question for all subjects).

We discuss right, left and interval censoring and how mishandling censoring can lead to bias and loss of sensitivity in tests that probe for differences in survival times.

Martin Krzywinski @MKrzywinski
Nature Methods Points of Significance column: Survival analysis—time-to-event data and censoring. (read)

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Survival analysis—time-to-event data and censoring. Nature Methods 19:906–908.

© 1999–2022 Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentreBC Cancer Research CenterBC CancerPHSA