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I created a font to encode genomic sequence on the wayfinding signs in my DNA on 10th public art project. Download the font it and make your own creations.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
1,708 quotes and all is well.

The archive contains 1,708 quotes. From Dorothy Parker to Pinky and Brain, you're sure to find something special.

There are quote collections about love, heart, desire, life, death, god, mind, science.

Feeling lucky? Read 10 random quotes. Well, will you, punk?

All quotes about desire

Some say the world will end in fire,
Some say in ice.
From what I’ve tasted of desire
I hold with those who favor fire.
But if it had to perish twice,
I think I know enough of hate
To say that for destruction ice
Is also great
And would suffice.
Robert Frost
Fire and Ice
What is it men in women do require?
The lineaments of gratified desire.
What is it women do in men require?
The lineaments of gratified desire.
William Blake
MS. Notebooks, 1793, p.99
I dare not ask a kiss;
I dare not beg a smile;
Lest having that, or this,
I might grow proud the while.
No, no, the utmost share
Of my desire, shall be
Only to kiss the air,
That lately kissed thee.
Robert Herrick
To Electra
There are two tragedies in life.
One is to lose your heart’s desire.
The other is to gain it.
George Bernard Shaw
Foeda est in coitu et brevis voluptas
Et taedet Veneris statim peractae.
[Delight of lust is gross and brief
And weariness treads on desire.]
I do desire we may be better strangers.
William Shakespeare
As You Like It, I.vii.276
They are not long, the weeping and the laughter,
Love and desire and hate:
I think they have no portion in us after
We pass the gate.
Ernest Dowson
Vitae Summa Brevis Spem Nos Vetat Incohare Longham
And Love! could thou and I with Fate conspire
To grasp this sorry Scheme of Things entire,
Would not we shatter it to bits—and then
Re-mould it nearer to the Heart’s Desire!
Omar Khayyam
Rubaiyat, LXXII, trans. by Edward Fitzgerald (1st ed.)
If I seek a lovelier part,
Where I travel goes my heart;
Where I stray my thought must go;
With me wanders my desire.
Best to sit and watch the snow,
Turn the lock, and poke the fire.
Dorothy Parker
April is the cruellest month, breeding
Lilacs out of the dead land, mixing
Memory out of desire, stirring
Dull roots with spring rain.
Winter kept us warm, covering
Earth in a forgetful snow, feeding
A little life with dried tubers.
T.S. Eliot
The Waste Land
Be thou my friend forever blest
Have friends selected from the best
Have all the sweethearts you desire
but be my sweetheart for this hour.
Will A. McCoy
Autograph Albums and Bible of Ella Beaver Calhoun
Desire not to live long but to live well,
How long we live not years, but actions tell.
Adda Ervin
Autograph Albums and Bible of Ella Beaver Calhoun
Mountains should be climbed with as little effort as possible and without desire. The reality of your own nature should determine the speed. If you become restless, speed up. If you become winded, slow down.
Robert M. Pirsig
Zen and the Art of Motorcycle Maintenance
news + thoughts

Neural network primer

Mon 06-02-2023

Nature is often hidden, sometimes overcome, seldom extinguished. —Francis Bacon

In the first of a series of columns about neural networks, we introduce them with an intuitive approach that draws from our discussion about logistic regression.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Neural network primer. (read)

Simple neural networks are just a chain of linear regressions. And, although neural network models can get very complicated, their essence can be understood in terms of relatively basic principles.

We show how neural network components (neurons) can be arranged in the network and discuss the ideas of hidden layers. Using a simple data set we show how even a 3-neuron neural network can already model relatively complicated data patterns.

Derry, A., Krzywinski, M & Altman, N. (2023) Points of significance: Neural network primer. Nature Methods 20.

Background reading

Lever, J., Krzywinski, M. & Altman, N. (2016) Points of significance: Logistic regression. Nature Methods 13:541–542.

Cell Genomics cover

Mon 16-01-2023

Our cover on the 11 January 2023 Cell Genomics issue depicts the process of determining the parent-of-origin using differential methylation of alleles at imprinted regions (iDMRs) is imagined as a circuit.

Designed in collaboration with with Carlos Urzua.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Our Cell Genomics cover depicts parent-of-origin assignment as a circuit (volume 3, issue 1, 11 January 2023). (more)

Akbari, V. et al. Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq (2023) Cell Genomics 3(1).

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Science Advances cover

Thu 05-01-2023

My cover design on the 6 January 2023 Science Advances issue depicts DNA sequencing read translation in high-dimensional space. The image showss 672 bases of sequencing barcodes generated by three different single-cell RNA sequencing platforms were encoded as oriented triangles on the faces of three 7-dimensional cubes.

More details about the design.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Science Advances cover that encodes sequence onto hypercubes (volume 9, issue 1, 6 January 2023). (more)

Kijima, Y. et al. A universal sequencing read interpreter (2023) Science Advances 9.

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Regression modeling of time-to-event data with censoring

Mon 21-11-2022

If you sit on the sofa for your entire life, you’re running a higher risk of getting heart disease and cancer. —Alex Honnold, American rock climber

In a follow-up to our Survival analysis — time-to-event data and censoring article, we look at how regression can be used to account for additional risk factors in survival analysis.

We explore accelerated failure time regression (AFTR) and the Cox Proportional Hazards model (Cox PH).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Regression modeling of time-to-event data with censoring. (read)

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Regression modeling of time-to-event data with censoring. Nature Methods 19.

Music video for Max Cooper's Ascent

Tue 25-10-2022

My 5-dimensional animation sets the visual stage for Max Cooper's Ascent from the album Unspoken Words. I have previously collaborated with Max on telling a story about infinity for his Yearning for the Infinite album.

I provide a walkthrough the video, describe the animation system I created to generate the frames, and show you all the keyframes

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Frame 4897 from the music video of Max Cooper's Asent.

The video recently premiered on YouTube.

Renders of the full scene are available as NFTs.

© 1999–2023 Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentreBC Cancer Research CenterBC CancerPHSA