Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - contact me Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Lumondo Photography Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Art Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Hilbertonians - Creatures on the Hilbert CurveMartin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Day 2020 - Piku
Lips that taste of tears, they say, are the best for kissing.Dorothy Parkerget crankymore quotes

typography: worthwhile


Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca

The Outbreak Poems — artistic emissions in a pandemic


art + design

Math geek? If you like the clean geometric design of the type posters, you may enjoy something even more mathematical. Design that transcends repetition: Art of Pi, Phi and e posters.
Are optotypes your type?
SnellenMK adds lowercase and punctuation to the traditional Snellen design.

Visions of Type

the intertypes

Letters give a type weight. Intertypes give a type cohesion.

The intertypes (my own term) are the spaces between letters. This poster shows all 26 ×26 = 686 intertypes for Helvetica Neue.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
The intertypes of Helvetica Neue. (BUY ARTWORK)

type peep show—the private curves of letters

Sometimes to understand the whole, we need to look more closely at its parts.

Completely safe for work.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Bodoni type peep show. (BUY ARTWORK)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Century type peep show. (BUY ARTWORK)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Dax type peep show. (BUY ARTWORK)

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Franklin Gothic type peep show. (BUY ARTWORK)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Futura type peep show. (BUY ARTWORK)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Gill Sans type peep show. (BUY ARTWORK)

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Helvetica type peep show. (BUY ARTWORK)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Minion type peep show. (BUY ARTWORK)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Platelet type peep show. (BUY ARTWORK)

I include Emigre's Platelet because it's such a goofy and fun font. One look at the lower case b and you know this isn't a type face that wears a tie.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Type peep show of nine faces. (BUY ARTWORK)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Type peep show of nine faces. (BUY ARTWORK)

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news + thoughts

Virus Mutations Reveal How COVID-19 Really Spread

Mon 01-06-2020

Genetic sequences of the coronavirus tell story of when the virus arrived in each country and where it came from.

Our graphic in Scientific American's Graphic Science section in the June 2020 issue shows a phylogenetic tree based on a snapshot of the data model from Nextstrain as of 31 March 2020.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Virus Mutations Reveal How COVID-19 Really Spread. Text by Mark Fischetti (Senior Editor), art direction by Jen Christiansen (Senior Graphics Editor), source: Nextstrain (enabled by data from GISAID).

Cover of Nature Cancer April 2020

Mon 27-04-2020

Our design on the cover of Nature Cancer's April 2020 issue shows mutation spectra of patients from the POG570 cohort of 570 individuals with advanced metastatic cancer.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Each ellipse system represents the mutation spectrum of an individual patient. Individual ellipses in the system correspond to the number of base changes in a given class and are layered by mutation count. Ellipse angle is controlled by the proportion of mutations in a class within the sample and its size is determined by a sigmoid mapping of mutation count scaled within the layer. The opacity of each system represents the duration since the diagnosis of advanced disease. (read more)

The cover design accompanies our report in the issue Pleasance, E., Titmuss, E., Williamson, L. et al. (2020) Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes. Nat Cancer 1:452–468.

Modeling infectious epidemics

Wed 06-05-2020

Every day sadder and sadder news of its increase. In the City died this week 7496; and of them, 6102 of the plague. But it is feared that the true number of the dead this week is near 10,000 ....
—Samuel Pepys, 1665

This month, we begin a series of columns on epidemiological models. We start with the basic SIR model, which models the spread of an infection between three groups in a population: susceptible, infected and recovered.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Modeling infectious epidemics. (read)

We discuss conditions under which an outbreak occurs, estimates of spread characteristics and the effects that mitigation can play on disease trajectories. We show the trends that arise when "flattenting the curve" by decreasing `R_0`.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Modeling infectious epidemics. (read)

This column has an interactive supplemental component that allows you to explore how the model curves change with parameters such as infectious period, basic reproduction number and vaccination level.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Modeling infectious epidemics. (Interactive supplemental materials)

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: Modeling infectious epidemics. Nature Methods 17:455–456.

The Outbreak Poems

Sat 04-04-2020

I'm writing poetry daily to put my feelings into words more often during the COVID-19 outbreak.

That moment
when
you know a moment.
Branch to branch,
flit,
look everywhere,
chirp.
Memory,
scent
of thought fleeting.
Distant pasts
all
ways in plural
form.

Read the poems and learn what a piku is.

Deadly Genomes: Genome Structure and Size of Harmful Bacteria and Viruses

Tue 17-03-2020

A poster full of epidemiological worry and statistics. Now updated with the genome of SARS-CoV-2 and COVID-19 case statistics as of 3 March 2020.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Deadly Genomes: Genome Structure and Size of Harmful Bacteria and Viruses (zoom)

Bacterial and viral genomes of various diseases are drawn as paths with color encoding local GC content and curvature encoding local repeat content. Position of the genome encodes prevalence and mortality rate.

The deadly genomes collection has been updated with a posters of the genomes of SARS-CoV-2, the novel coronavirus that causes COVID-19.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Genomes of 56 SARS-CoV-2 coronaviruses that causes COVID-19.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Ball of 56 SARS-CoV-2 coronaviruses that causes COVID-19.
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The first SARS-CoV-2 genome (MT019529) to be sequenced appears first on the poster.