Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - contact me Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Lumondo Photography Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Pi Art Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Hilbertonians - Creatures on the Hilbert Curve
This love's a nameless dream.Cocteau Twinstry to figure it outmore quotes

typography: beautiful



DNA on 10th — street art, wayfinding and font


art + design

Math geek? If you like the clean geometric design of the type posters, you may enjoy something even more mathematical. Design that transcends repetition: Art of Pi, Phi and e posters.
Are optotypes your type?
SnellenMK adds lowercase and punctuation to the traditional Snellen design.

Visions of Type

eye on the universe

Designed in the style of a Snellen eye chart, these posters insist that you look. Font is Rockwell.


Typographical posters of how the world works in the style of Snellen eye charts
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Snellen Chart of abundance of the elements in the universe. (BUY ARTWORK)

Typographical posters of how the world works in the style of Snellen eye charts
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Snellen Chart of physical constants. (BUY ARTWORK)

Typographical posters of how the world works in the style of Snellen eye charts
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Snellen Chart typeset in Braille. (BUY ARTWORK)

chirping in proxima nova

A new line of typographical posters featuring Proxima Nova. The posters present the bird song mnemonics against the plumage color of the bird.


Typographical posters of bird song
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Potato chip! — song of the American Goldfinch (Spinus tristis). (BUY ARTWORK)

Typographical posters of bird song
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Who cooks for you? — song of the Barred Owl (Strix varia). (BUY ARTWORK)

Typographical posters of bird song
 / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Clear. Wick, wick, wick. — song of the Northern Flicker (Colaptes auratus). (BUY ARTWORK)

letter forms, sensually revealed and stacked

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Type peep show — the private curves of letters. (BUY ARTWORK)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Sixteen ands — a consensus of conjunctions. (BUY ARTWORK)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca buy artwork
Sixteen faces — fonts in argument. (BUY ARTWORK)
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news + thoughts

Quantile regression

Sat 01-06-2019
Quantile regression robustly estimates the typical and extreme values of a response.

Quantile regression explores the effect of one or more predictors on quantiles of the response. It can answer questions such as "What is the weight of 90% of individuals of a given height?"

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Quantile regression. (read)

Unlike in traditional mean regression methods, no assumptions about the distribution of the response are required, which makes it practical, robust and amenable to skewed distributions.

Quantile regression is also very useful when extremes are interesting or when the response variance varies with the predictors.

Das, K., Krzywinski, M. & Altman, N. (2019) Points of significance: Quantile regression. Nature Methods 16:451–452.

Background reading

Altman, N. & Krzywinski, M. (2015) Points of significance: Simple linear regression. Nature Methods 12:999–1000.

Analyzing outliers: Robust methods to the rescue

Sat 30-03-2019
Robust regression generates more reliable estimates by detecting and downweighting outliers.

Outliers can degrade the fit of linear regression models when the estimation is performed using the ordinary least squares. The impact of outliers can be mitigated with methods that provide robust inference and greater reliability in the presence of anomalous values.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Analyzing outliers: Robust methods to the rescue. (read)

We discuss MM-estimation and show how it can be used to keep your fitting sane and reliable.

Greco, L., Luta, G., Krzywinski, M. & Altman, N. (2019) Points of significance: Analyzing outliers: Robust methods to the rescue. Nature Methods 16:275–276.

Background reading

Altman, N. & Krzywinski, M. (2016) Points of significance: Analyzing outliers: Influential or nuisance. Nature Methods 13:281–282.

Two-level factorial experiments

Fri 22-03-2019
To find which experimental factors have an effect, simultaneously examine the difference between the high and low levels of each.

Two-level factorial experiments, in which all combinations of multiple factor levels are used, efficiently estimate factor effects and detect interactions—desirable statistical qualities that can provide deep insight into a system.

They offer two benefits over the widely used one-factor-at-a-time (OFAT) experiments: efficiency and ability to detect interactions.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Two-level factorial experiments. (read)

Since the number of factor combinations can quickly increase, one approach is to model only some of the factorial effects using empirically-validated assumptions of effect sparsity and effect hierarchy. Effect sparsity tells us that in factorial experiments most of the factorial terms are likely to be unimportant. Effect hierarchy tells us that low-order terms (e.g. main effects) tend to be larger than higher-order terms (e.g. two-factor or three-factor interactions).

Smucker, B., Krzywinski, M. & Altman, N. (2019) Points of significance: Two-level factorial experiments Nature Methods 16:211–212.

Background reading

Krzywinski, M. & Altman, N. (2014) Points of significance: Designing comparative experiments.. Nature Methods 11:597–598.

Happy 2019 `\pi` Day—
Digits, internationally

Tue 12-03-2019

Celebrate `\pi` Day (March 14th) and set out on an exploration explore accents unknown (to you)!

This year is purely typographical, with something for everyone. Hundreds of digits and hundreds of languages.

A special kids' edition merges math with color and fat fonts.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
116 digits in 64 languages. (details)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
223 digits in 102 languages. (details)

Check out art from previous years: 2013 `\pi` Day and 2014 `\pi` Day, 2015 `\pi` Day, 2016 `\pi` Day, 2017 `\pi` Day and 2018 `\pi` Day.

Tree of Emotional Life

Sun 17-02-2019

One moment you're :) and the next you're :-.

Make sense of it all with my Tree of Emotional life—a hierarchical account of how we feel.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A section of the Tree of Emotional Life.