listen; there's a hell of a good universe next door: let's go.go theremore quotes

EMBO Practical Course: Bioinformatics and Genome Analysis, 5–17 June 2017.

# visualization + design

Working with senior graphics editor at Scientific American Jen Christiansen, I have designed three Graphic Science visualizations for the magazine.

December 2015. Composition of bacteria in household dust.
June 2015. Relationship between genes and traits.
September 2014. Similarity of human, Denisovan, chimp, bonobo, and gorilla genomes.

# Men and Women Alter a Home's Bacteria Differently

## An analysis of dust reveals how the presence of men, women, dogs and cats affects the variety of bacteria in a household

### December 2015, Scientific American Volume 313, Issue 6

This collaboration with Jeanine Hunnicutt explored differences in household dust bacteria based on the gender and pet status of the occupants.

We have also written about the making of the graphic, for those interested in how these things come together.

Graphic by Martin Krzywinski and Barbara Jeanine Hunnicutt.

Catalogue of bacteria shapes by Barbara Jeanine Hunnicutt.

Source: Barberan A et al. (2015) The ecology of microscopic life in household dust. Proc. R. Soc. B 282: 20151139.

# A Road Map to the "Volume Control" of Genes

## Genes, traits and disease are linked in complex and surprising ways

### June 2015, Scientific American Volume 312, Issue 6

Because sometimes only a network hairball will do.

Graphic by Martin Krzywinski.

Source: Integrative analysis of 111 reference human epigenomes. (2015) Nature 518:317.

# Tiny Genetic Differences between Humans and Other Primates Pervade the Genome

## Genome comparisons reveal the DNA that distinguishes Homo sapiens from its kin

### September 2014, Scientific American Volume 311, Issue 3

A Scientific American blog entry "A Monkey's Blueprint" accompanies this piece. I also have a more detailed description with links to data sources.

You can also read more about Hilbert curves and creatures that live on it, Hilbertonians.

This design won a bronze award at Malofiej 23. For more information about Malofiej, see the SA Visual blog entry "There's No Infographic without Info (and other Lessons from Malofiej)".

Graphic by Martin Krzywinski, illustrations by Portia Sloan Rollings.

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# Tabular Data

Tue 11-04-2017
Tabulating the number of objects in categories of interest dates back to the earliest records of commerce and population censuses.

After 30 columns, this is our first one without a single figure. Sometimes a table is all you need.

In this column, we discuss nominal categorical data, in which data points are assigned to categories in which there is no implied order. We introduce one-way and two-way tables and the $\chi^2$ and Fisher's exact tests.

Altman, N. & Krzywinski, M. (2017) Points of Significance: Tabular data. Nature Methods 14:329–330.

# Happy 2017 $\pi$ Day—Star Charts, Creatures Once Living and a Poem

Tue 14-03-2017

on a brim of echo,

capsized chamber
drawn into our constellation, and cooling.
—Paolo Marcazzan

Celebrate $\pi$ Day (March 14th) with star chart of the digits. The charts draw 40,000 stars generated from the first 12 million digits.

12,000,000 digits of $\pi$ interpreted as a star catalogue. (details)

The 80 constellations are extinct animals and plants. Here you'll find old friends and new stories. Read about how Desmodus is always trying to escape or how Megalodon terrorizes the poor Tecopa! Most constellations have a story.

Find friends and stories among the 80 constellations of extinct animals and plants. Oh look, a Dodo guardings his eggs! (details)

This year I collaborate with Paolo Marcazzan, a Canadian poet, who contributes a poem, Of Black Body, about space and things we might find and lose there.

Check out art from previous years: 2013 $\pi$ Day and 2014 $\pi$ Day, 2015 $\pi$ Day and and 2016 $\pi$ Day.

# Data in New Dimensions: convergence of art, genomics and bioinformatics

Tue 07-03-2017

Art is science in love.
— E.F. Weisslitz

A behind-the-scenes look at the making of our stereoscopic images which were at display at the AGBT 2017 Conference in February. The art is a creative collaboration with Becton Dickinson and The Linus Group.

Its creation began with the concept of differences and my writeup of the creative and design process focuses on storytelling and how concept of differences is incorporated into the art.

Oh, and this might be a good time to pick up some red-blue 3D glasses.

A stereoscopic image and its interpretive panel of single-cell transcriptomes of blood cells: diseased versus healthy control.

# Interpreting P values

Thu 02-03-2017
A P value measures a sample’s compatibility with a hypothesis, not the truth of the hypothesis.

This month we continue our discussion about $P$ values and focus on the fact that $P$ value is a probability statement about the observed sample in the context of a hypothesis, not about the hypothesis being tested.

Nature Methods Points of Significance column: Interpreting P values. (read)

Given that we are always interested in making inferences about hypotheses, we discuss how $P$ values can be used to do this by way of the Benjamin-Berger bound, $\bar{B}$ on the Bayes factor, $B$.

Heuristics such as these are valuable in helping to interpret $P$ values, though we stress that $P$ values vary from sample to sample and hence many sources of evidence need to be examined before drawing scientific conclusions.

Altman, N. & Krzywinski, M. (2017) Points of Significance: Interpreting P values. Nature Methods 14:213–214.