In your hiding, you're alone. Kept your treasures with my bones.crawl somewhere bettermore quotes

# making poetry out of spam is fun

In Silico Flurries: Computing a world of snow. Scientific American. 23 December 2017

# visualization + design

Working with senior graphics editor at Scientific American Jen Christiansen, I have designed these Graphic Science visualizations for the magazine.

January 2019. Daily phases of gene expression.
July 2018. Mental illness overlap.

December 2015. Composition of bacteria in household dust.
June 2015. Relationship between genes and traits.

September 2014. Similarity of human, Denisovan, chimp, bonobo, and gorilla genomes.

# Take your medicine ... now

## Drugs could be more effective if taken when proteins they target are more active

### Janunary 2019, Scientific American Volume 320, Issue 1

Graphic by Martin Krzywinski.

Source: Ruben et al. A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine Science Translational Medicine 10 Issue 458, eaat8806.

# The Same Genes May Underlie Different Psychiatric Disorders

## A distinct set of genes may underlie several psychiatric conditions

### July 2018, Scientific American Volume 319, Issue 1

The dataset is challenging: expression, correlation and network module membership of 11,000+ genes. Getting it onto one page was an exercise in restraint and calm.

Graphic by Martin Krzywinski.

Source: Gandal M.J. et al. Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap Science 359 693–697 (2018)

# Men and Women Alter a Home's Bacteria Differently

## An analysis of dust reveals how the presence of men, women, dogs and cats affects the variety of bacteria in a household

### December 2015, Scientific American Volume 313, Issue 6

This collaboration with Jeanine Hunnicutt explored differences in household dust bacteria based on the gender and pet status of the occupants.

We have also written about the making of the graphic, for those interested in how these things come together.

Graphic by Martin Krzywinski and Barbara Jeanine Hunnicutt.

Catalogue of bacteria shapes by Barbara Jeanine Hunnicutt.

Source: Barberan A et al. (2015) The ecology of microscopic life in household dust. Proc. R. Soc. B 282: 20151139.

# A Road Map to the "Volume Control" of Genes

## Genes, traits and disease are linked in complex and surprising ways

### June 2015, Scientific American Volume 312, Issue 6

Because sometimes only a network hairball will do.

Graphic by Martin Krzywinski.

Source: Integrative analysis of 111 reference human epigenomes. (2015) Nature 518:317.

# Tiny Genetic Differences between Humans and Other Primates Pervade the Genome

## Genome comparisons reveal the DNA that distinguishes Homo sapiens from its kin

### September 2014, Scientific American Volume 311, Issue 3

A Scientific American blog entry "A Monkey's Blueprint" accompanies this piece. I also have a more detailed description with links to data sources.

You can also read more about Hilbert curves and creatures that live on it, Hilbertonians.

This design won a bronze award at Malofiej 23. For more information about Malofiej, see the SA Visual blog entry "There's No Infographic without Info (and other Lessons from Malofiej)".

Graphic by Martin Krzywinski, illustrations by Portia Sloan Rollings.

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# Find and snap to colors in an image

Sat 29-12-2018

One of my color tools, the $colorsnap$ application snaps colors in an image to a set of reference colors and reports their proportion.

Below is Times Square rendered using the colors of the MTA subway lines.

Colors used by the New York MTA subway lines.

Times Square in New York City.
Times Square in New York City rendered using colors of the MTA subway lines.
Granger rainbow snapped to subway lines colors from four cities. (zoom)

# Take your medicine ... now

Wed 19-12-2018

Drugs could be more effective if taken when the genetic proteins they target are most active.

Design tip: rediscover CMYK primaries.

More of my American Scientific Graphic Science designs

Ruben et al. A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine Science Translational Medicine 10 Issue 458, eaat8806.

# Predicting with confidence and tolerance

Wed 07-11-2018
I abhor averages. I like the individual case. —J.D. Brandeis.

We focus on the important distinction between confidence intervals, typically used to express uncertainty of a sampling statistic such as the mean and, prediction and tolerance intervals, used to make statements about the next value to be drawn from the population.

Confidence intervals provide coverage of a single point—the population mean—with the assurance that the probability of non-coverage is some acceptable value (e.g. 0.05). On the other hand, prediction and tolerance intervals both give information about typical values from the population and the percentage of the population expected to be in the interval. For example, a tolerance interval can be configured to tell us what fraction of sampled values (e.g. 95%) will fall into an interval some fraction of the time (e.g. 95%).

Nature Methods Points of Significance column: Predicting with confidence and tolerance. (read)

Altman, N. & Krzywinski, M. (2018) Points of significance: Predicting with confidence and tolerance Nature Methods 15:843–844.