Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - contact me Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Lumondo Photography Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Pi Art Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Hilbertonians - Creatures on the Hilbert Curve
Twenty — minutes — maybe — more.Naomichoose four wordsmore quotes


DNA on 10th — street art, wayfinding and font


visualization + design

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca

Working with senior graphics editor at Scientific American Jen Christiansen, I have designed these Graphic Science visualizations for the magazine.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
January 2019. Daily phases of gene expression.
Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
July 2018. Mental illness overlap.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
December 2015. Composition of bacteria in household dust.
Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
June 2015. Relationship between genes and traits.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
September 2014. Similarity of human, Denisovan, chimp, bonobo, and gorilla genomes.
Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca

Take your medicine ... now

Drugs could be more effective if taken when proteins they target are more active

Janunary 2019, Scientific American Volume 320, Issue 1

Graphic by Martin Krzywinski.

Source: Ruben et al. A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine Science Translational Medicine 10 Issue 458, eaat8806.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca

The Same Genes May Underlie Different Psychiatric Disorders

A distinct set of genes may underlie several psychiatric conditions

July 2018, Scientific American Volume 319, Issue 1

The dataset is challenging: expression, correlation and network module membership of 11,000+ genes. Getting it onto one page was an exercise in restraint and calm.

Graphic by Martin Krzywinski.

Source: Gandal M.J. et al. Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap Science 359 693–697 (2018)

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca

Men and Women Alter a Home's Bacteria Differently

An analysis of dust reveals how the presence of men, women, dogs and cats affects the variety of bacteria in a household

December 2015, Scientific American Volume 313, Issue 6

This collaboration with Jeanine Hunnicutt explored differences in household dust bacteria based on the gender and pet status of the occupants.

We have also written about the making of the graphic, for those interested in how these things come together.

Graphic by Martin Krzywinski and Barbara Jeanine Hunnicutt.

Catalogue of bacteria shapes by Barbara Jeanine Hunnicutt.

Source: Barberan A et al. (2015) The ecology of microscopic life in household dust. Proc. R. Soc. B 282: 20151139.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca

A Road Map to the "Volume Control" of Genes

Genes, traits and disease are linked in complex and surprising ways

June 2015, Scientific American Volume 312, Issue 6

Because sometimes only a network hairball will do.

Graphic by Martin Krzywinski.

Source: Integrative analysis of 111 reference human epigenomes. (2015) Nature 518:317.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca

Tiny Genetic Differences between Humans and Other Primates Pervade the Genome

Genome comparisons reveal the DNA that distinguishes Homo sapiens from its kin

September 2014, Scientific American Volume 311, Issue 3

A Scientific American blog entry "A Monkey's Blueprint" accompanies this piece. I also have a more detailed description with links to data sources.

You can also read more about Hilbert curves and creatures that live on it, Hilbertonians.

This design won a bronze award at Malofiej 23. For more information about Malofiej, see the SA Visual blog entry "There's No Infographic without Info (and other Lessons from Malofiej)".

Graphic by Martin Krzywinski, illustrations by Portia Sloan Rollings.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
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news + thoughts

Scientific data visualization: Aesthetic for diagrammatic clarity

Mon 13-01-2020

The scientific process works because all its output is empirically constrained.

My chapter from The Aesthetics of Scientific Data Representation, More than Pretty Pictures, in which I discuss the principles of data visualization and connect them to the concept of "quality" introduced by Robert Pirsig in Zen and the Art of Motorcycle Maintenance.

Yearning for the Infinite — Aleph 2

Mon 18-11-2019

Discover Cantor's transfinite numbers through my music video for the Aleph 2 track of Max Cooper's Yearning for the Infinite (album page, event page).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Yearning for the Infinite, Max Cooper at the Barbican Hall, London. Track Aleph 2. Video by Martin Krzywinski. Photo by Michal Augustini. (more)

I discuss the math behind the video and the system I built to create the video.

Hidden Markov Models

Mon 18-11-2019

Everything we see hides another thing, we always want to see what is hidden by what we see.
—Rene Magritte

A Hidden Markov Model extends a Markov chain to have hidden states. Hidden states are used to model aspects of the system that cannot be directly observed and themselves form a Markov chain and each state may emit one or more observed values.

Hidden states in HMMs do not have to have meaning—they can be used to account for measurement errors, compress multi-modal observational data, or to detect unobservable events.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Hidden Markov Models. (read)

In this column, we extend the cell growth model from our Markov Chain column to include two hidden states: normal and sedentary.

We show how to calculate forward probabilities that can predict the most likely path through the HMM given an observed sequence.

Grewal, J., Krzywinski, M. & Altman, N. (2019) Points of significance: Hidden Markov Models. Nature Methods 16:795–796.

Background reading

Altman, N. & Krzywinski, M. (2019) Points of significance: Markov Chains. Nature Methods 16:663–664.

Hola Mundo Cover

Sat 21-09-2019

My cover design for Hola Mundo by Hannah Fry. Published by Blackie Books.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Hola Mundo by Hannah Fry. Cover design is based on my 2013 `\pi` day art. (read)

Curious how the design was created? Read the full details.