Martin Krzywinski / Genome Sciences Center / Martin Krzywinski / Genome Sciences Center / - contact me Martin Krzywinski / Genome Sciences Center / on Twitter Martin Krzywinski / Genome Sciences Center / - Lumondo Photography Martin Krzywinski / Genome Sciences Center / - Pi Art Martin Krzywinski / Genome Sciences Center / - Hilbertonians - Creatures on the Hilbert Curve
Lips that taste of tears, they say, are the best for kissing.Dorothy Parkerget crankymore quotes

dust: exciting

EMBO Practical Course: Bioinformatics and Genome Analysis, 5–17 June 2017.

visualization + design

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski

Working with senior graphics editor at Scientific American Jen Christiansen, I have designed three Graphic Science visualizations for the magazine.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski
December 2015. Composition of bacteria in household dust.
Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski
June 2015. Relationship between genes and traits.
Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski
September 2014. Similarity of human, Denisovan, chimp, bonobo, and gorilla genomes.

Men and Women Alter a Home's Bacteria Differently

An analysis of dust reveals how the presence of men, women, dogs and cats affects the variety of bacteria in a household

December 2015, Scientific American Volume 313, Issue 6

This collaboration with Jeanine Hunnicutt explored differences in household dust bacteria based on the gender and pet status of the occupants.

We have also written about the making of the graphic, for those interested in how these things come together.

Graphic by Martin Krzywinski and Barbara Jeanine Hunnicutt.

Catalogue of bacteria shapes by Barbara Jeanine Hunnicutt.

Source: Barberan A et al. (2015) The ecology of microscopic life in household dust. Proc. R. Soc. B 282: 20151139.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski

A Road Map to the "Volume Control" of Genes

Genes, traits and disease are linked in complex and surprising ways

June 2015, Scientific American Volume 312, Issue 6

Because sometimes only a network hairball will do.

Graphic by Martin Krzywinski.

Source: Integrative analysis of 111 reference human epigenomes. (2015) Nature 518:317.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski

Tiny Genetic Differences between Humans and Other Primates Pervade the Genome

Genome comparisons reveal the DNA that distinguishes Homo sapiens from its kin

September 2014, Scientific American Volume 311, Issue 3

A Scientific American blog entry "A Monkey's Blueprint" accompanies this piece. I also have a more detailed description with links to data sources.

You can also read more about Hilbert curves and creatures that live on it, Hilbertonians.

This design won a bronze award at Malofiej 23. For more information about Malofiej, see the SA Visual blog entry "There's No Infographic without Info (and other Lessons from Malofiej)".

Graphic by Martin Krzywinski, illustrations by Portia Sloan Rollings.

Scientific American Graphic Science - Martin Krzywinski. / Martin Krzywinski @MKrzywinski

news + thoughts

Happy 2017 `\pi` Day—Star Charts, Creatures Once Living and a Poem

Tue 14-03-2017

on a brim of echo,

capsized chamber
drawn into our constellation, and cooling.
—Paolo Marcazzan

Celebrate `\pi` Day (March 14th) with star chart of the digits. The charts draw 40,000 stars generated from the first 12 million digits.

Martin Krzywinski @MKrzywinski
12,000,000 digits of `\pi` interpreted as a star catalogue. (details)

The 80 constellations are extinct animals and plants. Here you'll find old friends and new stories. Read about how Desmodus is always trying to escape or how Megalodon terrorizes the poor Tecopa! Most constellations have a story.

Martin Krzywinski @MKrzywinski
Find friends and stories among the 80 constellations of extinct animals and plants. Oh look, a Dodo guardings his eggs! (details)

This year I collaborate with Paolo Marcazzan, a Canadian poet, who contributes a poem, Of Black Body, about space and things we might find and lose there.

Check out art from previous years: 2013 `\pi` Day and 2014 `\pi` Day, 2015 `\pi` Day and and 2016 `\pi` Day.

Data in New Dimensions: convergence of art, genomics and bioinformatics

Tue 07-03-2017

Art is science in love.
— E.F. Weisslitz

A behind-the-scenes look at the making of our stereoscopic images which were at display at the AGBT 2017 Conference in February. The art is a creative collaboration with Becton Dickinson and The Linus Group.

Its creation began with the concept of differences and my writeup of the creative and design process focuses on storytelling and how concept of differences is incorporated into the art.

Oh, and this might be a good time to pick up some red-blue 3D glasses.

BD Genomics 3D art exhibit - AGBT 2017 / Martin Krzywinski @MKrzywinski
A stereoscopic image and its interpretive panel of single-cell transcriptomes of blood cells: diseased versus healthy control.

Interpreting P values

Thu 02-03-2017
A P value measures a sample’s compatibility with a hypothesis, not the truth of the hypothesis.

This month we continue our discussion about `P` values and focus on the fact that `P` value is a probability statement about the observed sample in the context of a hypothesis, not about the hypothesis being tested.

Martin Krzywinski @MKrzywinski
Nature Methods Points of Significance column: Interpreting P values. (read)

Given that we are always interested in making inferences about hypotheses, we discuss how `P` values can be used to do this by way of the Benjamin-Berger bound, `\bar{B}` on the Bayes factor, `B`.

Heuristics such as these are valuable in helping to interpret `P` values, though we stress that `P` values vary from sample to sample and hence many sources of evidence need to be examined before drawing scientific conclusions.

Altman, N. & Krzywinski, M. (2017) Points of Significance: Interpreting P values. Nature Methods 14:213–214.

Background reading

Krzywinski, M. & Altman, N. (2017) Points of significance: P values and the search for significance. Nature Methods 14:3–4.

Krzywinski, M. & Altman, N. (2013) Points of significance: Significance, P values and t–tests. Nature Methods 10:1041–1042.

...more about the Points of Significance column

Snellen Charts—Typography to Really Look at

Sat 18-02-2017

Another collection of typographical posters. These ones really ask you to look.

Martin Krzywinski @MKrzywinski
Snellen charts designed using physical constants, Braille and elemental abundances in the universe and human body.

The charts show a variety of interesting symbols and operators found in science and math. The design is in the style of a Snellen chart and typset with the Rockwell font.