Working with senior graphics editor at Scientific American Jen Christiansen, I have designed three Graphic Science visualizations for the magazine.
The dataset is challenging: expression, correlation and network module membership of 11,000+ genes. Getting it onto one page was an exercise in restraint and calm.
Graphic by Martin Krzywinski.
Source: Gandal M.J. et al. Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap Science 359 693–697 (2018)
This collaboration with Jeanine Hunnicutt explored differences in household dust bacteria based on the gender and pet status of the occupants.
We have also written about the making of the graphic, for those interested in how these things come together.
Graphic by Martin Krzywinski and Barbara Jeanine Hunnicutt.
Catalogue of bacteria shapes by Barbara Jeanine Hunnicutt.
Source: Barberan A et al. (2015) The ecology of microscopic life in household dust. Proc. R. Soc. B 282: 20151139.
Because sometimes only a network hairball will do.
Graphic by Martin Krzywinski.
Source: Integrative analysis of 111 reference human epigenomes. (2015) Nature 518:317.
A Scientific American blog entry "A Monkey's Blueprint" accompanies this piece. I also have a more detailed description with links to data sources.
This design won a bronze award at Malofiej 23. For more information about Malofiej, see the SA Visual blog entry "There's No Infographic without Info (and other Lessons from Malofiej)".
Graphic by Martin Krzywinski, illustrations by Portia Sloan Rollings.
The presence of constraints in experiments, such as sample size restrictions, awkward blocking or disallowed treatment combinations may make using classical designs very difficult or impossible.
Optimal design is a powerful, general purpose alternative for high quality, statistically grounded designs under nonstandard conditions.
We discuss two types of optimal designs (D-optimal and I-optimal) and show how it can be applied to a scenario with sample size and blocking constraints.
Smucker, B., Krzywinski, M. & Altman, N. (2018) Points of significance: Optimal experimental design Nature Methods 15:599–600.
Krzywinski, M., Altman, N. (2014) Points of significance: Two factor designs. Nature Methods 11:1187–1188.
Krzywinski, M. & Altman, N. (2014) Points of significance: Analysis of variance (ANOVA) and blocking. Nature Methods 11:699–700.
Krzywinski, M. & Altman, N. (2014) Points of significance: Designing comparative experiments. Nature Methods 11:597–598.
An illustration of the Tree of Life, showing some of the key branches.
The tree is drawn as a DNA double helix, with bases colored to encode ribosomal RNA genes from various organisms on the tree.
All living things on earth descended from a single organism called LUCA (last universal common ancestor) and inherited LUCA’s genetic code for basic biological functions, such as translating DNA and creating proteins. Constant genetic mutations shuffled and altered this inheritance and added new genetic material—a process that created the diversity of life we see today. The “tree of life” organizes all organisms based on the extent of shuffling and alteration between them. The full tree has millions of branches and every living organism has its own place at one of the leaves in the tree. The simplified tree shown here depicts all three kingdoms of life: bacteria, archaebacteria and eukaryota. For some organisms a grey bar shows when they first appeared in the tree in millions of years (Ma). The double helix winding around the tree encodes highly conserved ribosomal RNA genes from various organisms.
Johnson, H.L. (2018) The Whole Earth Cataloguer, Sactown, Jun/Jul, p. 89
An article about keyboard layouts and the history and persistence of QWERTY.
McDonald, T. (2018) Why we can't give up this odd way of typing, BBC, 25 May 2018.
I've previously taken a more fine-art approach to cover design, such for those of Nature, Genome Research and Trends in Genetics. I've used microscopy images to create a cover for PNAS—the one that made biology look like astrophysics—and thought that this is kind of material I'd start with for the MCS cover.