Martin Krzywinski is a staff scientist at Canada’s Michael Smith Genome Sciences Centre.
Naomi Altman is a Professor of Statistics at The Pennsylvania State University.
Jorge López Puga is a Professor of Research Methodology at UCAM Universidad Católica de Murcia.
Paul Blainey is an Assistant Professor of Biological Engineering at MIT and Core Member of the Broad Institute.
Anthony Kulesa is a graduate student in the Department of Biological Engineering at MIT.
Jake Lever is a PhD candidate at Canada’s Michael Smith Genome Sciences Centre.
Danilo Bzdok is an Assistant Professor at the Department of Psychiatry, RWTH Aachen University, Germany, and a Visiting Professor at INRIA/Neurospin Saclay in France.
I've previously taken a more fine-art approach to cover design, such for those of Nature, Genome Research and Trends in Genetics. I've used microscopy images to create a cover for PNAS—the one that made biology look like astrophysics—and thought that this is kind of material I'd start with for the MCS cover.
A map of the nearby superclusters and voids in the Unvierse.
By "nearby" I mean within 6,000 million light-years.
It was now time to design my first ... pair of socks.
In collaboration with Flux Socks, the design features the colors and relative thicknesses of Rogue olympic weightlifting plates. The first four plates in the stack are the 55, 45, 35, and 25 competition plates. The top 4 plates are the 10, 5, 2.5 and 1.25 lb change plates.
The perceived weight of each sock is 178.75 lb and 357.5 lb for the pair.
The actual weight is much less.
Find patterns behind gene expression and disease.
Expression, correlation and network module membership of 11,000+ genes and 5 psychiatric disorders in about 6" x 7" on a single page.
Design tip: Stay calm.
Gandal M.J. et al. Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap Science 359 693–697 (2018)
We discuss the many ways in which analysis can be confounded when data has a large number of dimensions (variables). Collectively, these are called the "curses of dimensionality".
Some of these are unintuitive, such as the fact that the volume of the hypersphere increases and then shrinks beyond about 7 dimensions, while the volume of the hypercube always increases. This means that high-dimensional space is "mostly corners" and the distance between points increases greatly with dimension. This has consequences on correlation and classification.
Inference creates a mathematical model of the datageneration process to formalize understanding or test a hypothesis about how the system behaves. Prediction aims at forecasting unobserved outcomes or future behavior. Typically we want to do both and know how biological processes work and what will happen next. Inference and ML are complementary in pointing us to biologically meaningful conclusions.
Statistics asks us to choose a model that incorporates our knowledge of the system, and ML requires us to choose a predictive algorithm by relying on its empirical capabilities. Justification for an inference model typically rests on whether we feel it adequately captures the essence of the system. The choice of pattern-learning algorithms often depends on measures of past performance in similar scenarios.
Bzdok, D., Krzywinski, M. & Altman, N. (2018) Points of Significance: Statistics vs machine learning. Nature Methods 15:233–234.
Bzdok, D., Krzywinski, M. & Altman, N. (2017) Points of Significance: Machine learning: a primer. Nature Methods 14:1119–1120.
Bzdok, D., Krzywinski, M. & Altman, N. (2017) Points of Significance: Machine learning: supervised methods. Nature Methods 15:5–6.
Celebrate `\pi` Day (March 14th) and go to brand new places. Together with Jake Lever, this year we shrink the world and play with road maps.
Streets are seamlessly streets from across the world. Finally, a halva shop on the same block!
Intriguing and personal patterns of urban development for each city appear in the Boonies, Burbs and Boutiques series.
No color—just lines. Lines from Marrakesh, Prague, Istanbul, Nice and other destinations for the mind and the heart.