latest newsbuy art
Trance opera—Spente le Stellebe dramaticmore quotes
very clickable
communication + science
The Nature Methods Points of Significance column is an educational resource to all authors that provides practical suggestions about best practices in statistical analysis and reporting.

Nature Methods: Points of View

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Points of View column in Nature Methods. (Points of View)

The first Points of View column was about color coding in the July 2010 issue of Nature Methods. In its 5 year history, the column has established a significant legacy— it is one of the most frequently accessed parts of Nature Methods. The community sees the value in clear and effective visual communication and acknowledges the need for a forum in which best practices in the field are presented practically and accessibly.

2010–2012

Bang Wong, in collaboration with visiting authors (Noam Shoresh, Nils Gehlenborg, Cydney Nielsen and Rikke Schmidt Kjærgaard), has penned 29 columns in the period of August 2010 to December 2012, covering broad topics such as salience, Gestalt principles, color, typography, negative space, layout, and data integration.

2012–2014

The announcement of the return of the column, together with its history and a description of me, the new author, are available at the Nature Methods methagora blog. Humor is kept by repeated reference to my now-dead-but-once-famous pet rat.

When it was A.C. Greyling's turn to speak at a debate in which Christopher Hitchens and Richard Dawkins already made their points, Greyling said

When one gets up to speak this late in a debate, one is a bit tempated to quote that Hungarian M.P. who after a long, long, long discussion in the parliament in Budapest stood up and said, "Everything has been said but not everybody said it yet." (watch on YouTube)

Indeed, this is quite how I feel after being offered to be the new author of Nature Methods Point of View column. Both Bang and Hitchens provide significant inspiration for me, so Greyling's words are particularly fitting.

To improve on the column is impossible. My challenge is to identify useful topics that have not yet been covered. I will be working closely with Nature Methods and Bang to ensure that the columns strike the right balance of topic, tone and timbre.

In 2013 the Points of View column spawned the Points of Significance column, which deals with statistics in biological science.

For the month of August 2013, the entire set of 35 columns is available for free.

2015 and beyond

The column continues to run, though no longer monthly.

A PDF eBook of the 38 Points of View articles published between August 2010 and February 2015 is now available at the Nature Shop for $7.99 under the title Visual strategies for biological data: the collected Points of View.

news + thoughts

Cell Genomics cover

Mon 16-01-2023

Our cover on the 11 January 2023 Cell Genomics issue depicts the process of determining the parent-of-origin using differential methylation of alleles at imprinted regions (iDMRs) is imagined as a circuit.

Designed in collaboration with with Carlos Urzua.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Our Cell Genomics cover depicts parent-of-origin assignment as a circuit (volume 3, issue 1, 11 January 2023). (more)

Akbari, V. et al. Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq (2023) Cell Genomics 3(1).

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Science Advances cover

Thu 05-01-2023

My cover design on the 6 January 2023 Science Advances issue depicts DNA sequencing read translation in high-dimensional space. The image showss 672 bases of sequencing barcodes generated by three different single-cell RNA sequencing platforms were encoded as oriented triangles on the faces of three 7-dimensional cubes.

More details about the design.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Science Advances cover that encodes sequence onto hypercubes (volume 9, issue 1, 6 January 2023). (more)

Kijima, Y. et al. A universal sequencing read interpreter (2023) Science Advances 9

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Regression modeling of time-to-event data with censoring

Mon 21-11-2022

If you sit on the sofa for your entire life, you’re running a higher risk of getting heart disease and cancer. —Alex Honnold, American rock climber

In a follow-up to our Survival analysis — time-to-event data and censoring article, we look at how regression can be used to account for additional risk factors in survival analysis.

We explore accelerated failure time regression (AFTR) and the Cox Proportional Hazards model (Cox PH).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Regression modeling of time-to-event data with censoring. (read)

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Regression modeling of time-to-event data with censoring. Nature Methods 19.

Music video for Max Cooper's Ascent

Tue 25-10-2022

My 5-dimensional animation sets the visual stage for Max Cooper's Ascent from the album Unspoken Words. I have previously collaborated with Max on telling a story about infinity for his Yearning for the Infinite album.

I provide a walkthrough the video, describe the animation system I created to generate the frames, and show you all the keyframes

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Frame 4897 from the music video of Max Cooper's Asent.

The video recently premiered on YouTube.

Renders of the full scene are available as NFTs.


© 1999–2023 Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentreBC Cancer Research CenterBC CancerPHSA