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With the publication of Uncertainty and the Management of Epidemics, we celebrate our 50th column! Since 2013, our Nature Methods Points of Significance has been offering crisp explanations and practical suggestions about best practices in statistical analysis and reporting. To all our readers and coauthors: thank you and see you in the next column!

Nature Methods: Points of View

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Points of View column in Nature Methods. (Points of View)
1 | Krzywinski M 2016 Intuitive design Nat Methods 13:895.
2 | Krzywinski M 2016 Binning high-resolution data Nat Methods 13:463.
3 | Hunnicutt BJ & Krzywinski M 2016 Neural circuit diagrams Nat Methods 13:189.
4 | Hunnicutt BJ & Krzywinski M 2016 Pathways Nat Methods 13:5.
5 | McInerny G & Krzywinski M 2015 Unentangling complex plots Nat Methods 12:591.
6 | Streit M & Gehlenborg N 2015 Temporal Data Nat Methods 12:97.
7 | Lex A & Gehlenborg N 2014 Sets and Intersections Nat Methods 11:778.
8 | Streit M & Gehlenborg N 2014 Bar charts and box plots Nat Methods 11:117.
9 | Krzywinski M & Cairo A 2013 Storytelling Nat Methods 10:687.
10 | Krzywinski M & Savig E 2013 Multidimensional Data Nat Methods 10:595.
11 | Krzywinski M & Wong B 2013 Plotting symbols Nat Methods 10:451.
12 | Krzywinski M 2013 Elements of visual style Nat Methods 10:371.
13 | Krzywinski M 2013 Labels and callouts Nat Methods 10:275.
14 | Krzywinski M 2013 Axes, ticks and grids Nat Methods 10:183.
15 | Wong B 2012 Visualizing biological data Nat Methods 9:1131.
16 | Wong B & Kjaegaard RS 2012 Pencil and paper Nat Methods 9:1037.
17 | Gehlenborg N & Wong B 2012 Power of the plane Nat Methods 9:935.
18 | Gehlenborg N & Wong B 2012 Into the third dimension Nat Methods 9:851.
19 | Gehlenborg N & Wong B 2012 Mapping quantitative data to color Nat Methods 9:769.
20 | Nielsen C & Wong B 2012 Representing genomic structural variation Nat Methods 9:631.
21 | Nielsen C & Wong B 2012 Managing deep data in genome browsers Nat Methods 9:521.
22 | Nielsen C & Wong B 2012 Representing the genome Nat Methods 9:423.
23 | Gehlenborg N & Wong B 2012 Integrating data Nat Methods 9:315.
24 | Gehlenborg N & Wong B 2012 Heat maps Nat Methods 9:213.
25 | Gehlenborg N & Wong B 2012 Networks Nat Methods 9:115.
26 | Shoresh N & Wong B 2012 Data exploration Nat Methods 9:5.
27 | Wong B 2011 The design process Nat Methods 8:987.
28 | Wong B 2011 Salience to relevance Nat Methods 8:889.
29 | Wong B 2011 Layout Nat Methods 8:783.
30 | Wong B 2011 Arrows Nat Methods 8:701.
31 | Wong B 2011 Simplify to clarify Nat Methods 8:611.
32 | Wong B 2011 Avoiding color Nat Methods 8:525.
33 | Wong B 2011 Color blindness Nat Methods 8:441.
34 | Wong B 2011 The overview figure Nat Methods 8:365.
35 | Wong B 2011 Typography Nat Methods 8:277.
36 | Wong B 2011 Points of review (part 2) Nat Methods 8:189.
37 | Wong B 2011 Points of review (part 1) Nat Methods 8:101.
38 | Wong B 2011 Negative space Nat Methods 8:5.
39 | Wong B 2010 Gestalt principles (part 2) Nat Methods 7:941.
40 | Wong B 2010 Gestalt principles (part 1) Nat Methods 7:863.
41 | Wong B 2010 Salience Nat Methods 7:773.
42 | Wong B 2010 Design of data figures Nat Methods 7:665.
43 | Wong B 2010 Color coding Nat Methods 7:573.
news + thoughts

Cell Genomics cover

Mon 16-01-2023

Our cover on the 11 January 2023 Cell Genomics issue depicts the process of determining the parent-of-origin using differential methylation of alleles at imprinted regions (iDMRs) is imagined as a circuit.

Designed in collaboration with with Carlos Urzua.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Our Cell Genomics cover depicts parent-of-origin assignment as a circuit (volume 3, issue 1, 11 January 2023). (more)

Akbari, V. et al. Parent-of-origin detection and chromosome-scale haplotyping using long-read DNA methylation sequencing and Strand-seq (2023) Cell Genomics 3(1).

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Science Advances cover

Thu 05-01-2023

My cover design on the 6 January 2023 Science Advances issue depicts DNA sequencing read translation in high-dimensional space. The image showss 672 bases of sequencing barcodes generated by three different single-cell RNA sequencing platforms were encoded as oriented triangles on the faces of three 7-dimensional cubes.

More details about the design.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Science Advances cover that encodes sequence onto hypercubes (volume 9, issue 1, 6 January 2023). (more)

Kijima, Y. et al. A universal sequencing read interpreter (2023) Science Advances 9

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Regression modeling of time-to-event data with censoring

Mon 21-11-2022

If you sit on the sofa for your entire life, you’re running a higher risk of getting heart disease and cancer. —Alex Honnold, American rock climber

In a follow-up to our Survival analysis — time-to-event data and censoring article, we look at how regression can be used to account for additional risk factors in survival analysis.

We explore accelerated failure time regression (AFTR) and the Cox Proportional Hazards model (Cox PH).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Regression modeling of time-to-event data with censoring. (read)

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Regression modeling of time-to-event data with censoring. Nature Methods 19.

Music video for Max Cooper's Ascent

Tue 25-10-2022

My 5-dimensional animation sets the visual stage for Max Cooper's Ascent from the album Unspoken Words. I have previously collaborated with Max on telling a story about infinity for his Yearning for the Infinite album.

I provide a walkthrough the video, describe the animation system I created to generate the frames, and show you all the keyframes

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Frame 4897 from the music video of Max Cooper's Asent.

The video recently premiered on YouTube.

Renders of the full scene are available as NFTs.


© 1999–2023 Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentreBC Cancer Research CenterBC CancerPHSA