Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - contact me Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Lumondo Photography Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Art Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Hilbertonians - Creatures on the Hilbert CurveMartin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Day 2020 - Piku
Safe, fallen down this way, I want to be just what I am.Cocteau Twinssafe at lastmore quotes

genomes: layered


The Outbreak Poems — artistic emissions in a pandemic


data visualization + art
The Personal OncoGenomics Program (POG) is a research initiative to study the impact of embedding genomic sequencing into real-time treatment planning for BC patients with metastatic cancers. Based out of the BC Cancer Research Centre and the GSC, POG is a large world-class clinical research collaboration of BC Cancer oncologists, pathologists and other clinical staff, researchers and technical personnel throughout BC healthcare facilities.
Interested in more art based on the POG570 cohort from the Personal OncoGenomics Program? Check out our 5-year POG anniversary posters and desktops.

Nature Cancer Cover — April 2020 issue

Pan-cancer genomic landscapes of advanced tumors after therapy

Pleasance, E., Titmuss, E., Williamson, L. et al. (2020) Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes. Nat Cancer 1:452–468.

Art is science in love.
— E.F. Weisslitz

4k desktops

Download all desktops.

The legend at the bottom of the desktop provides credits and reads

Mutation spectra of patients from the POG570 cohort of 570 individuals with advanced metastatic cancer.
Each ellipse system represents the mutation spectrum of an individual patient. Individual ellipses in the system correspond to the number of base changes in a given class and are layered by mutation count. Ellipse angle is controlled by the proportion of mutations in a class within the sample and its size is determined by a sigmoid mapping of mutation count scaled within the layer. The opacity of each system represents the duration since the diagnosis of advanced disease.

The desktop show all the 570 mutation spectra. Cases are sorted in chronological order of time of enrollment, with the oldest case first to the most recent, which is shown last. This is the reverse order to what is shown on the poster.

The last set of desktops is a remix of randomly placed ellipses. For those with visually insatiable appetites.

Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Design of the Nature Cancer April 2020 cover accompanying Pan-cancer genomic landscapes of advanced tumors after therapy. (4k resolution)
Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Design of the Nature Cancer April 2020 cover accompanying Pan-cancer genomic landscapes of advanced tumors after therapy. (4k resolution)
Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Design of the Nature Cancer April 2020 cover accompanying Pan-cancer genomic landscapes of advanced tumors after therapy. (4k resolution)
Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Design of the Nature Cancer April 2020 cover accompanying Pan-cancer genomic landscapes of advanced tumors after therapy. (4k resolution)
Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Design of the Nature Cancer April 2020 cover accompanying Pan-cancer genomic landscapes of advanced tumors after therapy. (4k resolution)
Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Design of the Nature Cancer April 2020 cover accompanying Pan-cancer genomic landscapes of advanced tumors after therapy. (4k resolution)

random remixes

Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Random remix of the design. (4k resolution)
Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Random remix of the design. (4k resolution)
Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Random remix of the design. (4k resolution)

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news + thoughts

Cover of Nature Genetics August 2020

Mon 03-08-2020

Our design on the cover of Nature Genetics's August 2020 issue is “Dichotomy of Chromatin in Color” . Thanks to Dr. Andy Mungall for suggesting this terrific title.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dichotomy of Chromatin in Color. Nature Genetics, August 2020 issue. (read more)

The cover design accompanies our report in the issue Gagliardi, A., Porter, V.L., Zong, Z. et al. (2020) Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes. Nature Genetics 52:800–810.

Poster Design Guidelines

Wed 15-07-2020

Clear, concise, legible and compelling.

The PDF template is a poster about making posters. It provides design, typography and data visualiation tips with minimum fuss. Follow its advice until you have developed enough design sobriety and experience to know when to go your own way.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Poster Design Guidelines — Clear, concise, legible and compelling..

The SEIRS model for infectious disease dynamics

Thu 18-06-2020

Realistic models of epidemics account for latency, loss of immunity, births and deaths.

We continue with our discussion about epidemic models and show how births, deaths and loss of immunity can create epidemic waves—a periodic fluctuation in the fraction of population that is infected.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: The SEIRS model for infectious disease dynamics. (read)

This column has an interactive supplemental component (download code) that allows you to explore epidemic waves and introduces the idea of the phase plane, a compact way to understand the evolution of an epidemic over its entire course.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: The SEIRS model for infectious disease dynamics. (Interactive supplemental materials)

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: The SEIRS model for infectious disease dynamics. Nature Methods 17:557–558.

Background reading

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: Modeling infectious epidemics. Nature Methods 17:455–456.

Gene Machines

Fri 05-06-2020

Shifting soundscapes, textures and rhythmic loops produced by laboratory machines.

In commemoration of the 20th anniversary of Canada's Michael Smith Genome Sciences Centre, Segue was commissioned to create an original composition based on audio recordings from the GSC's laboratory equipment, robots and computers—to make “music” from the noise they produce.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Gene Machines by Segue. Now available on vinyl.

Virus Mutations Reveal How COVID-19 Really Spread

Mon 01-06-2020

Genetic sequences of the coronavirus tell story of when the virus arrived in each country and where it came from.

Our graphic in Scientific American's Graphic Science section in the June 2020 issue shows a phylogenetic tree based on a snapshot of the data model from Nextstrain as of 31 March 2020.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Virus Mutations Reveal How COVID-19 Really Spread. Text by Mark Fischetti (Senior Editor), art direction by Jen Christiansen (Senior Graphics Editor), source: Nextstrain (enabled by data from GISAID).