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Twenty — minutes — maybe — more.Naomichoose four wordsmore quotes

infinity: beyond


Scientific graphical abstracts — design guidelines


data visualization + art

Aleph 2 Music video from Max Cooper's Yearning for the Infinite album. Music by Max Cooper. Animation by Martin Krzywinski.
Yearning for the Infinite - Max Cooper and Martin Krzywinski - Visualization of Infinity and Pi
Telling a story about infinity is tricky.
Especially a short one.

Infinity in Just Over Six Minutes

To Infinity and beyond!
—Buzz Lightyear

Yearning for the Infinite - Max Cooper and Martin Krzywinski - Visualization of Infinity and Pi / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Max Cooper at the London Barbican Hall performing Yearning for the Infinite. (Michal Augustini) (Watch Barbican Hall performance)

In collaboration with Max Cooper, we told a story about infinity in 6 minutes and 34 seconds.

This was the Aleph 2 track on Max's latest album, Yearning for the Infinite.

In science one tries to tell people,
in such a way as to be understood by everyone,
something that no one ever knew before.
But in poetry, it’s the exact opposite.
—Paul Dirac, Mathematical Circles Adieu by H. Eves [quoted]

We chose a low-fi terminal style using the Classic Console font by Csaba Széll. I extended the font to include more set theory symbols.

The animation was closely synchronized to the music, all the while trying to avoid looking too much like something from the Matrix movie.

Yearning for the Infinite - Max Cooper and Martin Krzywinski - Visualization of Infinity and Pi / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Various bijections between the naturals and integers. The music is speeding up. Screenshot from Max Cooper's Yearning for the Infinite. (Alex Cooper / Martin Krzywinski)

These pages describe the system I build to generate the animation and the mathematics behind infinity, including sets, cardinality, countability, $\aleph$ and the Continuum Hypothesis.

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news + thoughts

Graphical Abstract Design Guidelines

Fri 13-11-2020

Clear, concise, legible and compelling.

Making a scientific graphical abstract? Refer to my practical design guidelines and redesign examples to improve organization, design and clarity of your graphical abstracts.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Graphical Abstract Design Guidelines — Clear, concise, legible and compelling.

"This data might give you a migrane"

Tue 06-10-2020

An in-depth look at my process of reacting to a bad figure — how I design a poster and tell data stories.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A poster of high BMI and obesity prevalence for 185 countries.

He said, he said — a word analysis of the 2020 Presidential Debates

Thu 01-10-2020

Building on the method I used to analyze the 2008, 2012 and 2016 U.S. Presidential and Vice Presidential debates, I explore word usagein the 2020 Debates between Donald Trump and Joe Biden.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Analysis of word usage by parts of speech for Trump and Biden reveals insight into each candidate.

Points of Significance celebrates 50th column

Mon 24-08-2020

We are celebrating the publication of our 50th column!

To all our coauthors — thank you and see you in the next column!

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance: Celebrating 50 columns of clear explanations of statistics. (read)

Uncertainty and the management of epidemics

Mon 24-08-2020

When modelling epidemics, some uncertainties matter more than others.

Public health policy is always hampered by uncertainty. During a novel outbreak, nearly everything will be uncertain: the mode of transmission, the duration and population variability of latency, infection and protective immunity and, critically, whether the outbreak will fade out or turn into a major epidemic.

The uncertainty may be structural (which model?), parametric (what is `R_0`?), and/or operational (how well do masks work?).

This month, we continue our exploration of epidemiological models and look at how uncertainty affects forecasts of disease dynamics and optimization of intervention strategies.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Uncertainty and the management of epidemics. (read)

We show how the impact of the uncertainty on any choice in strategy can be expressed using the Expected Value of Perfect Information (EVPI), which is the potential improvement in outcomes that could be obtained if the uncertainty is resolved before making a decision on the intervention strategy. In other words, by how much could we potentially increase effectiveness of our choice (e.g. lowering total disease burden) if we knew which model best reflects reality?

This column has an interactive supplemental component (download code) that allows you to explore the impact of uncertainty in `R_0` and immunity duration on timing and size of epidemic waves and the total burden of the outbreak and calculate EVPI for various outbreak models and scenarios.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Uncertainty and the management of epidemics. (Interactive supplemental materials)

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: Uncertainty and the management of epidemics. Nature Methods 17.

Background reading

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: Modeling infectious epidemics. Nature Methods 17:455–456.

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: The SEIRS model for infectious disease dynamics. Nature Methods 17:557–558.

Cover of Nature Genetics August 2020

Mon 03-08-2020

Our design on the cover of Nature Genetics's August 2020 issue is “Dichotomy of Chromatin in Color” . Thanks to Dr. Andy Mungall for suggesting this terrific title.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dichotomy of Chromatin in Color. Nature Genetics, August 2020 issue. (read more)

The cover design accompanies our report in the issue Gagliardi, A., Porter, V.L., Zong, Z. et al. (2020) Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes. Nature Genetics 52:800–810.