Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - contact me Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Lumondo Photography Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Pi Art Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Hilbertonians - Creatures on the Hilbert Curve
Safe, fallen down this way, I want to be just what I am.Cocteau Twinssafe at lastmore quotes

laughter: fun


In Silico Flurries: Computing a world of snow. Scientific American. 23 December 2017


fun + amusement

Dummer — Like Nothing Else


The Hummer font is a slightly modified Antique Olive Nord. The Like Nothing Else tag line is Trade Gothic. Both have character widths increased to 110-120% and individually adjusted kerning. Get the Illustrator CS5 file for both logos.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Hummer logo. (EPS, PNG)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer logo. (EPS, PNG)
Download high-resolution images.

This project might give you the impression that I don't like Hummers. You'd be right.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
It could be worse. But not by much. (zoom)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
It could be worse. But not by much. (zoom)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
It could be worse. But not by much. (zoom)

update

The Maurauder. Over 25,000 lb — five times what an H3 weighs. Enough said.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
There is always someone with a bigger one. (Manufacturer's page.)

Dummer - Like Nothing Else

Hummers are a cultural equivalent of a toxic warning label and have the same effect on me as bug spray on mosquitoes.

I am not the first one to satirize this automotive aberration, so there's some hope.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like Nothing Else. (New York Times — Laugh Lines)

GM's advertisement images require no modification for the satire, which makes it all that much better.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dumb and Dumber. (New York Times — Laugh Lines)

I could have just as well used the Lincoln Navigator or Cadillac Escalade, but they don't embody the superlative like the Hummer.

The Hummer brand proved itself to be aesthetically, rationally and economically unsustainable and collapsed after a failed attempt to sell it to China. There continues to be a robust market for used Hummers. Let the farce continue.

I'm hated

It delights me that this project produced my first hate mail.

I want to meet Doug and give him a hug for adding another dimension to this project.

I'm loved

The images got picked up by the New York Times laughlines blog, which drew a couple of fan mails.

But neither made me feel as good as Doug's email.

Dummer Images

Dummer. Like nothing else. A pretty good Hummer satire. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like nothing else. (zoom)
Dummer. Like nothing else. A pretty good Hummer satire. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like nothing else. (zoom)
Dummer. Like nothing else. A pretty good Hummer satire. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like nothing else. (zoom)
Dummer. Like nothing else. A pretty good Hummer satire. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like nothing else. (zoom)
Dummer. Like nothing else. A pretty good Hummer satire. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like nothing else. (zoom)
Dummer. Like nothing else. A pretty good Hummer satire. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like nothing else. (zoom)
Dummer. Like nothing else. A pretty good Hummer satire. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like nothing else. (zoom)
Dummer. Like nothing else. A pretty good Hummer satire. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like nothing else. (zoom)
Dummer. Like nothing else. A pretty good Hummer satire. / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dummer. Like nothing else. (zoom)
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news + thoughts

Predicting with confidence and tolerance

Wed 07-11-2018
I abhor averages. I like the individual case. —J.D. Brandeis.

We focus on the important distinction between confidence intervals, typically used to express uncertainty of a sampling statistic such as the mean and, prediction and tolerance intervals, used to make statements about the next value to be drawn from the population.

Confidence intervals provide coverage of a single point—the population mean—with the assurance that the probability of non-coverage is some acceptable value (e.g. 0.05). On the other hand, prediction and tolerance intervals both give information about typical values from the population and the percentage of the population expected to be in the interval. For example, a tolerance interval can be configured to tell us what fraction of sampled values (e.g. 95%) will fall into an interval some fraction of the time (e.g. 95%).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Predicting with confidence and tolerance. (read)

Altman, N. & Krzywinski, M. (2018) Points of significance: Predicting with confidence and tolerance Nature Methods 15:843–844.

Background reading

Krzywinski, M. & Altman, N. (2013) Points of significance: Importance of being uncertain. Nature Methods 10:809–810.

4-day Circos course

Wed 31-10-2018

A 4-day introductory course on genome data parsing and visualization using Circos. Prepared for the Bioinformatics and Genome Analysis course in Institut Pasteur Tunis, Tunis, Tunisia.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Composite of the kinds of images you will learn to make in this course.

Oryza longistaminata genome cake

Mon 24-09-2018

Data visualization should be informative and, where possible, tasty.

Stefan Reuscher from Bioscience and Biotechnology Center at Nagoya University celebrates a publication with a Circos cake.

The cake shows an overview of a de-novo assembled genome of a wild rice species Oryza longistaminata.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Circos cake celebrating Reuscher et al. 2018 publication of the Oryza longistaminata genome.

Optimal experimental design

Tue 31-07-2018
Customize the experiment for the setting instead of adjusting the setting to fit a classical design.

The presence of constraints in experiments, such as sample size restrictions, awkward blocking or disallowed treatment combinations may make using classical designs very difficult or impossible.

Optimal design is a powerful, general purpose alternative for high quality, statistically grounded designs under nonstandard conditions.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Optimal experimental design. (read)

We discuss two types of optimal designs (D-optimal and I-optimal) and show how it can be applied to a scenario with sample size and blocking constraints.

Smucker, B., Krzywinski, M. & Altman, N. (2018) Points of significance: Optimal experimental design Nature Methods 15:599–600.

Background reading

Krzywinski, M., Altman, N. (2014) Points of significance: Two factor designs. Nature Methods 11:1187–1188.

Krzywinski, M. & Altman, N. (2014) Points of significance: Analysis of variance (ANOVA) and blocking. Nature Methods 11:699–700.

Krzywinski, M. & Altman, N. (2014) Points of significance: Designing comparative experiments. Nature Methods 11:597–598.