resources
visualizations
presentations
lunch break
Distractions and amusements, with a sandwich and coffee.
writing
Writing
Poetry
Inked Sadness is a collection of poems written in that difficult time between being no longer young, but not yet old.
Expressions and Conversations of Love are short heart-breakers.
Scripts
Proverbial Man considers how our names and expectations limit our perceptions and freedoms. No answers are offered. I don't think I finished this.
The Surrogate echoes my own fears of fleeing from Poland in the early 80s. Or at least the fears I retroactively erected, to add drama. Count on the Polish for drama.
Narrative
Thirty Reasons should be enough to decide a place isn't worth returning to.
NeverEnder — Epic Space Poem
By my friend and colleague Emanuele Raffaele Ettore Libertini, the NeverEnder is a voyage through space and words.
news + thoughts
Genome Sciences Center 20th Anniversary Clothing, Music, Drinks and Art
Science. Timeliness. Respect.
Read about the design of the clothing, music, drinks and art for the Genome Sciences Center 20th Anniversary Celebration, held on 15 November 2019.
As part of the celebration and with the help of our engineering team, we framed 48 flow cells from the lab.
Each flow cell was accompanied by an interpretive plaque explaining the technology behind the flow cell and the sample information and sequence content.
Scientific data visualization: Aesthetic for diagrammatic clarity
The scientific process works because all its output is empirically constrained.
My chapter from The Aesthetics of Scientific Data Representation, More than Pretty Pictures, in which I discuss the principles of data visualization and connect them to the concept of "quality" introduced by Robert Pirsig in Zen and the Art of Motorcycle Maintenance.
Yearning for the Infinite — Aleph 2
Discover Cantor's transfinite numbers through my music video for the Aleph 2 track of Max Cooper's Yearning for the Infinite (album page, event page).
I discuss the math behind the video and the system I built to create the video.
Hidden Markov Models
Everything we see hides another thing, we always want to see what is hidden by what we see.
—Rene Magritte
A Hidden Markov Model extends a Markov chain to have hidden states. Hidden states are used to model aspects of the system that cannot be directly observed and themselves form a Markov chain and each state may emit one or more observed values.
Hidden states in HMMs do not have to have meaning—they can be used to account for measurement errors, compress multi-modal observational data, or to detect unobservable events.
In this column, we extend the cell growth model from our Markov Chain column to include two hidden states: normal and sedentary.
We show how to calculate forward probabilities that can predict the most likely path through the HMM given an observed sequence.
Grewal, J., Krzywinski, M. & Altman, N. (2019) Points of significance: Hidden Markov Models. Nature Methods 16:795–796.
Background reading
Altman, N. & Krzywinski, M. (2019) Points of significance: Markov Chains. Nature Methods 16:663–664.