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Distractions and amusements, with a sandwich and coffee.

This love's a nameless dream.
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If you like space, you'll love my 2017 Pi Day art which imagines the digits as a star catalogue. Meet the Quagga and Aurochs—the Constellations in this sky are extinct animals and plants.

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— Viorica Hrincu

Sometimes when you stare at the void, the void sends you a poem.

The average density of the universe is about `10 \times 10^{-30} \text{ g/cm}^3` or about 6 protons per cubic meter. This should put some perspective in what we mean when we speak about voids as "underdense regions".

All distances on the poster are expressed in terms of the light travel distance.

Distances in the universe can be expressed as either the light-travel distance or the comoving distance to the object. The first tells us how long light took to travel from the object to us.

For example, the furthest object observed is the galaxy GN-Z11 and its light-travel distance is 13 billion light-years (Gly).

But because space has expanded during the time the light from GN-Z11 has been travelling to us, the galaxy is now actually much further away. This is measured by its comoving distance which accounts for space expansion, which is 29.3 Gly for GN-Z11.

The redshift, `z`, is commonly used to specify distance, since it's a quantity that can be observed. For GN-Z11, `z = 11.09`.

To calculate these distances, the redshift `z` is used along with a few cosmological parameters.

The Hubble parameter, `H(z)`, is the function used for these calculations. It can be derived from the Friedmann equation. $$ H(z) = H_0 \sqrt { \Omega_r({1+z})^4 + \Omega_m({1+z})^3 + \Omega_k({1+z})^2 + \Omega_\Lambda } $$

The values of the parameters in `H(z)` are being continually refined and the values of some depend on various assumptions. I use the Hubble constant `H_0 = 69.6 \text{ km/s/Mpc}`, mass density of relativistic particles `\Omega_r = 8.6 \times 10^{-5}`, mass density `\Omega_m = 0.286`, curvature `\Omega_k = 0` and dark energy fraction `\Omega_\Lambda = 1 - \Omega_r - \Omega_m - \Omega_k = 0.713914`.

Bennett, C.L. et al The 1% Concordance Hubble Constant *Astrophysical Journal* **794**
(2014)

Now given a redshift, `z` the light-travel distance is $$ d_T(z) = c \int_0^z \frac{dx}{({1+x})E(x)} $$

The age of the universe can be computed from this expression. The edge of the universe has an infinite redshift so w can calculate it using `\lim_{z \rightarrow \infty} d_T(z)`.

The comoving distance to the object with redshift `z` is $$ d_C(z) = c \int_0^z \frac{dx}{E(x)} $$

It's convenient to express the above integrals by making a variable substitution. Using the scale factor `a = 1/(1+z)`, $$E(a) = H_0 \sqrt { \frac{\Omega_r}{a^2} + \frac{\Omega_m}{a} + \Omega_k + a^4\Omega_\Lambda } $$

The light-travel distance is $$D_T(z) = c \int_a^1 \frac{dx}{E(x)}$$

The comoving distance is $$D_C(z) = c \int_a^1 \frac{dx}{xE(x)}$$

The light-travel distance to the edge of the universe is $$D_{T_U}(z) = c \int_0^1 \frac{dx}{E(x)}$$

and the light-travel distance from the edge of the universe to the object as we're observing it now is $$D_{T_0}(z) = c \int_0^a \frac{dx}{E(x)}$$

which can be interpreted as the age of the object when it emitted the light that we're seeing now.

The proper size of the universe is the comoving distance to its edge, $$D_{C_U}(z) = c \int_0^1 \frac{dx}{xE(x)}$$

Below you can You can download the full script.

### Cosmological distance calculator ### Martin Krzywinski, 2018 # # The full script supports command-line parameters # http://mkweb.bcgsc.ca/universe-voids-and-superclusters/cosmology_distance.py z = 1 # redshift a = 1/(1+z) # scale factor Wm = 0.286 # mass density Wr = 8.59798189985467e-05 # relativistic mass Wk = 0 # curvature WV = 1 - Wm - Wr - Wk # dark matter fraction n = 10000 # integration steps # Hubble parameter, as function of a = 1/(1+z) def Ea(a,Wr,Wm,Wk,WV): return(math.sqrt(Wr/a**2 + Wm/a + Wk + WV*a**2)) H0 = 69.6 # Hubble constant c = 299792.458 # speed of light, km/s pc = 3.26156 # parsec to light-year conversion mult = (c/H0)*pc/1e3 # integrals are in units of c/H0, converts to Gy or Gly sum_comoving = 0 sum_light = 0 sum_univage = 0 sum_univsize = 0 for i in range(n): f = (i+0.5)/n x = a + (1-a) * f # a .. 1 xx = f # 0 .. 1 ex = Ea(x,args.Wr,args.Wm,args.Wk,args.WV) exx = Ea(xx,args.Wr,args.Wm,args.Wk,args.WV) sum_comoving += (1-a)/(x*ex) sum_light += (1-a)/( ex) sum_univsize += 1/(xx*exx) sum_univage += 1/( exx) results = [mult*i for i in [sum_univage,sum_univsize,sum_univage-sum_light, \ sum_light,sum_comoving]] print("z {:.2f} U {:f} Gy {:f} Gly T0 {:f} Gy T {:f} Gly C {:f} Gly". \ format(args.z,*results))

Use the script to generate distances for a given redshift, `z`. For example,

# For galaxy GN-Z11, furtest object ever observed ./cosmology_distance.py -z 11.09 z 11.09 U 13.720 Gy 46.441 Gly T0 0.414 Gy T 13.306 Gly C 32.216 Gly

The galaxy GN-Z11 has a light-travel distance of 13.3 Gly and a comoving distance of 32.2 Gly. We're seeing it now as it was only 0.4 Gy after the beginning of the universe, which is 13.7 Gy old and the distance to its edge is 46.4 Gly.

# For quasar J1342+0928, furthest quasar ever observed ./cosmology_distance.py -z 7.54 z 7.54 U 13.720 Gy 46.441 Gly T0 0.699 Gy T 13.021 Gly C 29.355 Gly

The values for U (age and size of universe), will always be the same for a given set of cosmological parameters for any value of `z`. I include them in the output of the script for convenience.

These values match those generated by Ned's online cosmological calculator for a flat universe.

The presence of constraints in experiments, such as sample size restrictions, awkward blocking or disallowed treatment combinations may make using classical designs very difficult or impossible.

Optimal design is a powerful, general purpose alternative for high quality, statistically grounded designs under nonstandard conditions.

We discuss two types of optimal designs (D-optimal and I-optimal) and show how it can be applied to a scenario with sample size and blocking constraints.

Smucker, B., Krzywinski, M. & Altman, N. (2018) Points of significance: Optimal experimental design *Nature Methods* **15**:599–600.

Krzywinski, M., Altman, N. (2014) Points of significance: Two factor designs. Nature Methods 11:1187–1188.

Krzywinski, M. & Altman, N. (2014) Points of significance: Analysis of variance (ANOVA) and blocking. Nature Methods 11:699–700.

Krzywinski, M. & Altman, N. (2014) Points of significance: Designing comparative experiments. Nature Methods 11:597–598.

An illustration of the Tree of Life, showing some of the key branches.

The tree is drawn as a DNA double helix, with bases colored to encode ribosomal RNA genes from various organisms on the tree.

All living things on earth descended from a single organism called LUCA (last universal common ancestor) and inherited LUCA’s genetic code for basic biological functions, such as translating DNA and creating proteins. Constant genetic mutations shuffled and altered this inheritance and added new genetic material—a process that created the diversity of life we see today. The “tree of life” organizes all organisms based on the extent of shuffling and alteration between them. The full tree has millions of branches and every living organism has its own place at one of the leaves in the tree. The simplified tree shown here depicts all three kingdoms of life: bacteria, archaebacteria and eukaryota. For some organisms a grey bar shows when they first appeared in the tree in millions of years (Ma). The double helix winding around the tree encodes highly conserved ribosomal RNA genes from various organisms.

Johnson, H.L. (2018) The Whole Earth Cataloguer, Sactown, Jun/Jul, p. 89

An article about keyboard layouts and the history and persistence of QWERTY.

My Carpalx keyboard optimization software is mentioned along with my World's Most Difficult Layout: TNWMLC. True typing hell.

McDonald, T. (2018) Why we can't give up this odd way of typing, BBC, 25 May 2018.

The theme of the April issue of Molecular Case Studies is precision oncogenomics. We have three papers in the issue based on work done in our Personalized Oncogenomics Program (POG).

The covers of Molecular Case Studies typically show microscopy images, with some shown in a more abstract fashion. There's also the occasional Circos plot.

I've previously taken a more fine-art approach to cover design, such for those of Nature, Genome Research and Trends in Genetics. I've used microscopy images to create a cover for PNAS—the one that made biology look like astrophysics—and thought that this is kind of material I'd start with for the MCS cover.

A map of the nearby superclusters and voids in the Unvierse.

By "nearby" I mean within 6,000 million light-years.