And whatever I do will become forever what I've done.don't rehearsemore quotes

# a: 2

In Silico Flurries: Computing a world of snow. Scientific American. 23 December 2017

# data visualization + art

If you like space, you'll love my 2017 Pi Day art which imagines the digits as a star catalogue. Meet the Quagga and Aurochs—the Constellations in this sky are extinct animals and plants.

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— Viorica Hrincu

Sometimes when you stare at the void, the void sends you a poem.

# Universe—Superclusters and Voids

The Universe — Superclustesr and Voids. The two supergalactic hemispheres showing Abell clusters (blue), superclusters (magenta) and voids (black) within a distance of 6,000 million light-years from the Milky Way.

The average density of the universe is about $10 \times 10^{-30} \text{ g/cm}^3$ or about 6 protons per cubic meter. This should put some perspective in what we mean when we speak about voids as "underdense regions".

A variety of color schemes are available.

For each poster, I show an image of a close crop of the region near Ursa Major.

The Universe — Superclusters and Voids. The two supergalactic hemispheres showing Abell clusters, superclusters and voids within a distance of 6 billion light-travel years from the Milky Way.. Magenta theme. (BUY ARTWORK)
(ZOOM) The Universe — Superclusters and Voids. The two supergalactic hemispheres showing Abell clusters, superclusters and voids within a distance of 6 billion light-travel years from the Milky Way.. Magenta theme. (BUY ARTWORK)
The Universe — Superclusters and Voids. The two supergalactic hemispheres showing Abell clusters, superclusters and voids within a distance of 6 billion light-travel years from the Milky Way.. Blue theme. (BUY ARTWORK)
(ZOOM) The Universe — Superclusters and Voids. The two supergalactic hemispheres showing Abell clusters, superclusters and voids within a distance of 6 billion light-travel years from the Milky Way.. Blue theme. (BUY ARTWORK)
The Universe — Superclusters and Voids. The two supergalactic hemispheres showing Abell clusters, superclusters and voids within a distance of 6 billion light-travel years from the Milky Way.. Grey/blue theme. (BUY ARTWORK)
(ZOOM) The Universe — Superclusters and Voids. The two supergalactic hemispheres showing Abell clusters, superclusters and voids within a distance of 6 billion light-travel years from the Milky Way.. Grey/blue theme. (BUY ARTWORK)
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# Predicting with confidence and tolerance

Wed 07-11-2018
I abhor averages. I like the individual case. —J.D. Brandeis.

We focus on the important distinction between confidence intervals, typically used to express uncertainty of a sampling statistic such as the mean and, prediction and tolerance intervals, used to make statements about the next value to be drawn from the population.

Confidence intervals provide coverage of a single point—the population mean—with the assurance that the probability of non-coverage is some acceptable value (e.g. 0.05). On the other hand, prediction and tolerance intervals both give information about typical values from the population and the percentage of the population expected to be in the interval. For example, a tolerance interval can be configured to tell us what fraction of sampled values (e.g. 95%) will fall into an interval some fraction of the time (e.g. 95%).

Nature Methods Points of Significance column: Predicting with confidence and tolerance. (read)

Altman, N. & Krzywinski, M. (2018) Points of significance: Predicting with confidence and tolerance Nature Methods 15:843–844.

Krzywinski, M. & Altman, N. (2013) Points of significance: Importance of being uncertain. Nature Methods 10:809–810.

# 4-day Circos course

Wed 31-10-2018

A 4-day introductory course on genome data parsing and visualization using Circos. Prepared for the Bioinformatics and Genome Analysis course in Institut Pasteur Tunis, Tunis, Tunisia.

Composite of the kinds of images you will learn to make in this course.

# Oryza longistaminata genome cake

Mon 24-09-2018

Data visualization should be informative and, where possible, tasty.

Stefan Reuscher from Bioscience and Biotechnology Center at Nagoya University celebrates a publication with a Circos cake.

The cake shows an overview of a de-novo assembled genome of a wild rice species Oryza longistaminata.

Circos cake celebrating Reuscher et al. 2018 publication of the Oryza longistaminata genome.

# Optimal experimental design

Tue 31-07-2018
Customize the experiment for the setting instead of adjusting the setting to fit a classical design.

The presence of constraints in experiments, such as sample size restrictions, awkward blocking or disallowed treatment combinations may make using classical designs very difficult or impossible.

Optimal design is a powerful, general purpose alternative for high quality, statistically grounded designs under nonstandard conditions.

Nature Methods Points of Significance column: Optimal experimental design. (read)

We discuss two types of optimal designs (D-optimal and I-optimal) and show how it can be applied to a scenario with sample size and blocking constraints.

Smucker, B., Krzywinski, M. & Altman, N. (2018) Points of significance: Optimal experimental design Nature Methods 15:599–600.

Krzywinski, M., Altman, N. (2014) Points of significance: Two factor designs. Nature Methods 11:1187–1188.

Krzywinski, M. & Altman, N. (2014) Points of significance: Analysis of variance (ANOVA) and blocking. Nature Methods 11:699–700.

Krzywinski, M. & Altman, N. (2014) Points of significance: Designing comparative experiments. Nature Methods 11:597–598.

# The Whole Earth Cataloguer

Mon 30-07-2018
All the living things.

An illustration of the Tree of Life, showing some of the key branches.

The tree is drawn as a DNA double helix, with bases colored to encode ribosomal RNA genes from various organisms on the tree.

The circle of life. (read, zoom)

All living things on earth descended from a single organism called LUCA (last universal common ancestor) and inherited LUCA’s genetic code for basic biological functions, such as translating DNA and creating proteins. Constant genetic mutations shuffled and altered this inheritance and added new genetic material—a process that created the diversity of life we see today. The “tree of life” organizes all organisms based on the extent of shuffling and alteration between them. The full tree has millions of branches and every living organism has its own place at one of the leaves in the tree. The simplified tree shown here depicts all three kingdoms of life: bacteria, archaebacteria and eukaryota. For some organisms a grey bar shows when they first appeared in the tree in millions of years (Ma). The double helix winding around the tree encodes highly conserved ribosomal RNA genes from various organisms.

Johnson, H.L. (2018) The Whole Earth Cataloguer, Sactown, Jun/Jul, p. 89

# Why we can't give up this odd way of typing

Mon 30-07-2018
All fingers report to home row.

An article about keyboard layouts and the history and persistence of QWERTY.

My Carpalx keyboard optimization software is mentioned along with my World's Most Difficult Layout: TNWMLC. True typing hell.

TNWMLC requires seriously flexible digits. It’s 87% more difficult than using a standard Qwerty keyboard, according to Martin Krzywinski, who created it (Credit: Ben Nelms). (read)

McDonald, T. (2018) Why we can't give up this odd way of typing, BBC, 25 May 2018.