Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - contact me Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Lumondo Photography Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Art Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Hilbertonians - Creatures on the Hilbert CurveMartin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Day 2020 - Piku
Drive, driven. Gave, given.YelloGive me a number of games.more quotes


PNAS Cover: Earth BioGenome Project


circos

data viewer with comparative genomics in mind

martin krzywinski

Click on an image to view next image. Download presentation as pdf png jpg pptx ppt. More about Circos. Circos - data viewer - introduction - page 1 Circos - data viewer - introduction - page 2 Circos - data viewer - introduction - page 3 Circos - data viewer - introduction - page 4 Circos - data viewer - introduction - page 5 Circos - data viewer - introduction - page 6 Circos - data viewer - introduction - page 7 Circos - data viewer - introduction - page 8 Circos - data viewer - introduction - page 9 Circos - data viewer - introduction - page 10 Circos - data viewer - introduction - page 11 Circos - data viewer - introduction - page 12 Circos - data viewer - introduction - page 13 Circos - data viewer - introduction - page 14 Circos - data viewer - introduction - page 15 Circos - data viewer - introduction - page 16 Circos - data viewer - introduction - page 17 Circos - data viewer - introduction - page 18 Circos - data viewer - introduction - page 19 Circos - data viewer - introduction - page 20 Circos - data viewer - introduction - page 21 Circos - data viewer - introduction - page 22 Circos - data viewer - introduction - page 23 Circos - data viewer - introduction - page 24 Circos - data viewer - introduction - page 25 Circos - data viewer - introduction - page 26 Circos - data viewer - introduction - page 27 Circos - data viewer - introduction - page 28 Circos - data viewer - introduction - page 29 Circos - data viewer - introduction - page 30 Circos - data viewer - introduction - page 31 Circos - data viewer - introduction - page 32 Circos - data viewer - introduction - page 33 Circos - data viewer - introduction - page 34 Circos - data viewer - introduction - page 35 Circos - data viewer - introduction - page 36 Circos - data viewer - introduction - page 37 Circos - data viewer - introduction - page 38 Circos - data viewer - introduction - page 39 Circos - data viewer - introduction - page 40 Circos - data viewer - introduction - page 41 Circos - data viewer - introduction - page 42 Circos - data viewer - introduction - page 43 Circos - data viewer - introduction - page 44 Circos - data viewer - introduction - page 45 Circos - data viewer - introduction - page 46 Circos - data viewer - introduction - page 47 Circos - data viewer - introduction - page 48 Circos - data viewer - introduction - page 49 Circos - data viewer - introduction - page 50 Circos - data viewer - introduction - page 51 Circos - data viewer - introduction - page 52 Circos - data viewer - introduction - page 53 Circos - data viewer - introduction - page 54

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news + thoughts

Survival analysis—time-to-event data and censoring

Fri 05-08-2022

Love's the only engine of survival. —L. Cohen

We begin a series on survival analysis in the context of its two key complications: skew (which calls for the use of probability distributions, such as the Weibull, that can accomodate skew) and censoring (required because we almost always fail to observe the event in question for all subjects).

We discuss right, left and interval censoring and how mishandling censoring can lead to bias and loss of sensitivity in tests that probe for differences in survival times.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Survival analysis—time-to-event data and censoring. (read)

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Survival analysis—time-to-event data and censoring. Nature Methods 19:906–908.

3,117,275,501 Bases, 0 Gaps

Fri 05-08-2022

See How Scientists Put Together the Complete Human Genome.

My graphic in Scientific American's Graphic Science section in the August 2022 issue shows the full history of the human genome assembly — from its humble shotgun beginnings to the gapless telomere-to-telomere assembly.

Read about the process and methods behind the creation of the graphic.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
3,117,275,501 Bases, 0 Gaps. Text by Clara Moskowitz (Senior Editor), art direction by Jen Christiansen (Senior Graphics Editor), source: UCSC Genome Browser.

See all my Scientific American Graphic Science visualizations.

Anatomy of SARS-Cov-2

Tue 31-05-2022

My poster showing the genome structure and position of mutations on all SARS-CoV-2 variants appears in the March/April 2022 issue of American Scientist.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Deadly Genomes: Genome Structure and Size of Harmful Bacteria and Viruses (zoom)

An accompanying piece breaks down the anatomy of each genome — by gene and ORF, oriented to emphasize relative differences that are caused by mutations.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Deadly Genomes: Genome Structure and Size of Harmful Bacteria and Viruses (zoom)

Cancer Cell cover

Sat 23-04-2022

My cover design on the 11 April 2022 Cancer Cell issue depicts depicts cellular heterogeneity as a kaleidoscope generated from immunofluorescence staining of the glial and neuronal markers MBP and NeuN (respectively) in a GBM patient-derived explant.

LeBlanc VG et al. Single-cell landscapes of primary glioblastomas and matched explants and cell lines show variable retention of inter- and intratumor heterogeneity (2022) Cancer Cell 40:379–392.E9.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Cancer Cell kaleidoscope cover (volume 40, issue 4, 11 April 2022). (more)

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Nature Biotechnology cover

Sat 23-04-2022

My cover design on the 4 April 2022 Nature Biotechnology issue is an impression of a phylogenetic tree of over 200 million sequences.

Konno N et al. Deep distributed computing to reconstruct extremely large lineage trees (2022) Nature Biotechnology 40:566–575.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Nature Biotechnology phylogenetic tree cover (volume 40, issue 4, 4 April 2022). (more)

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Nature cover — Gene Genie

Sat 23-04-2022

My cover design on the 17 March 2022 Nature issue depicts the evolutionary properties of sequences at the extremes of the evolvability spectrum.

Vaishnav ED et al. The evolution, evolvability and engineering of gene regulatory DNA (2022) Nature 603:455–463.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Nature squiggles cover (volume 603, issue 7901, 17 March 2022). (more)

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)


me as a keyword list

aikido | analogies | animals | astronomy | comfortable silence | cosmology | dorothy parker | drumming | espresso | fundamental forces | good kerning | graphic design | humanism | humour | jean michel jarre | kayaking | latin | little fluffy clouds | lord of the rings | mathematics | negative space | nuance | perceptual color palettes | philosophy of science | photography | physical constants | physics | poetry | pon farr | reason | rhythm | richard feynman | science | secularism | swing | symmetry and its breaking | technology | things that make me go hmmm | typography | unix | victoria arduino | wine | words