latest newsbuy art
listen; there's a hell of a good universe next door: let's go.e.e. cummingsgo theremore quotes
very clickable
data visualization + art
The rationale, strategy and roadmap for the Earth BioGenome Project were originally presented in Harris, A. et al. (2018) Earth BioGenome Project: Sequencing life for the future of life. PNAS 115(17):4325–4333.

PNAS cover — Earth BioGenome Project

An enlightened perspective on our planet

Lewin HA et al., The Earth BioGenome Project 2020: Starting the clock. (2022) PNAS 119(4) e2115635118
My science art has appeared on the covers of many journals, including Nature, Science, PNAS, Cancer Cell and American Scientist.

1 · The cover

Here, you can read about the method behind the design of the PNAS 25 January 2022 issue.

Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A view of Earth that captures the vision of the Earth BioGenome Project — understanding and conserving genetic diversity on a global scale. Continents from the Authagraph projection, which preserves areas and shapes, are represented as a double helix of 32,111 bases. Short sequences of 806 unique species, sequenced as part of EBP-affiliated projects, are mapped onto the double helix of the continent (or ocean) where the species is commonly found. The length of the sequence is the same for each species on a continent (or ocean) and the sequences are separated by short gaps. Individual bases of the sequence are colored by dots. Species appear along the path in alphabetical order (by Latin name) and the first base of the first species is identified by a small black triangle. PNAS (cover) | vol 119 | no 4 | 25 January 2022.
Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca

2 · A place familiar

In Africa, 87 species are represented, from the aggressively cute Acomys cahirinus (Egyptian spiny mouse) to the shrill "bi-joo" Xerus inauris (South African ground squirrel).

Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A crop of Africa with sequences of 87 species, of which at least one says "bi-joo".

3 · A place strange

In Antarctica, we have the fluttering Oceanites oceanicus (Wilson's storm-petrel) and the strident Chionis minor (Black-faced sheethbill).

Martin Krzywinski / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A crop of Antarctica. Two species can be found here: Oceanites oceanicus (Wilson's storm-petrel, 79653) and Chionis minor (Black-faced sheethbill, 227182).
news + thoughts

Regression modeling of time-to-event data with censoring

Mon 21-11-2022

If you sit on the sofa for your entire life, you’re running a higher risk of getting heart disease and cancer. —Alex Honnold, American rock climber

In a follow-up to our Survival analysis — time-to-event data and censoring article, we look at how regression can be used to account for additional risk factors in survival analysis.

We explore accelerated failure time regression (AFTR) and the Cox Proportional Hazards model (Cox PH).

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Regression modeling of time-to-event data with censoring. (read)

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Regression modeling of time-to-event data with censoring. Nature Methods 19.

Music video for Max Cooper's Ascent

Tue 25-10-2022

My 5-dimensional animation sets the visual stage for Max Cooper's Ascent from the album Unspoken Words. I have previously collaborated with Max on telling a story about infinity for his Yearning for the Infinite album.

I provide a walkthrough the video, describe the animation system I created to generate the frames, and show you all the keyframes

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Frame 4897 from the music video of Max Cooper's Asent.

The video recently premiered on YouTube.

Renders of the full scene are available as NFTs.

Gene Cultures exhibit — art at the MIT Museum

Tue 25-10-2022

I am more than my genome and my genome is more than me.

The MIT Museum reopened at its new location on 2nd October 2022. The new Gene Cultures exhibit featured my visualization of the human genome, which walks through the size and organization of the genome and some of the important structures.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My art at the MIT Museum Gene Cultures exhibit tells shows the scale and structure of the human genome. Pay no attention to the pink chicken.

Annals of Oncology cover

Wed 14-09-2022

My cover design on the 1 September 2022 Annals of Oncology issue shows 570 individual cases of difficult-to-treat cancers. Each case shows the number and type of actionable genomic alterations that were detected and the length of therapies that resulted from the analysis.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
An organic arrangement of 570 individual cases of difficult-to-treat cancers showing genomic changes and therapies. Apperas on Annals of Oncology cover (volume 33, issue 9, 1 September 2022).

Pleasance E et al. Whole-genome and transcriptome analysis enhances precision cancer treatment options (2022) Annals of Oncology 33:939–949.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My Annals of Oncology 570 cancer cohort cover (volume 33, issue 9, 1 September 2022). (more)

Browse my gallery of cover designs.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A catalogue of my journal and magazine cover designs. (more)

Survival analysis—time-to-event data and censoring

Fri 05-08-2022

Love's the only engine of survival. —L. Cohen

We begin a series on survival analysis in the context of its two key complications: skew (which calls for the use of probability distributions, such as the Weibull, that can accomodate skew) and censoring (required because we almost always fail to observe the event in question for all subjects).

We discuss right, left and interval censoring and how mishandling censoring can lead to bias and loss of sensitivity in tests that probe for differences in survival times.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Survival analysis—time-to-event data and censoring. (read)

Dey, T., Lipsitz, S.R., Cooper, Z., Trinh, Q., Krzywinski, M & Altman, N. (2022) Points of significance: Survival analysis—time-to-event data and censoring. Nature Methods 19:906–908.


© 1999–2022 Martin Krzywinski | contact | Canada's Michael Smith Genome Sciences CentreBC Cancer Research CenterBC CancerPHSA