Lips that taste of tears, they say, are the best for kissing.get crankymore quotes

# circles: beautiful

DNA on 10th — street art, wayfinding and font

# visualization + design

The 2019 Pi Day art celebrates digits of $\pi$ with hundreds of languages and alphabets. If you're a kid at heart—rejoice—there's a special edition for you!

# The art of Pi ($\pi$), Phi ($\phi$) and $e$

2019 $\pi$ has hundreds of digits, hundreds of languages and a special kids' edition.
2018 $\pi$ day
2017 $\pi$ day
2016 $\pi$ approximation day
2016 $\pi$ day
2015 $\pi$ day
2014 $\pi$ approx day
2014 $\pi$ day
2013 $\pi$ day
Circular $\pi$ art

This section contains various art work based on $\pi$, $\phi$ and $e$ that I created over the years.

Some of the numerical art reveals interesting and unexpected observations. For example, the sequence 999999 in π at digit 762 called the Feynman Point. Or that if you calculate π to 13,099,586 digits you will find love.

$\pi$ day art and $\pi$ approximation day art is kept separate.

For some time I have been thinking about creating minimalist typographical art based on the digits of $\pi$. The $i$-ness $\pi$ project was one of my first forays into this kind of art.

For each $i$th digit in $\pi$, $\pi_i$, its $i$-ness is the average of the distance between $\pi_i$ and its $n$ neighbouring digits.

The $i$-ness is a general property based on the neighbours of a digit. When $i$ is assigned a fixed value (e.g., $i=4$) then the average distance is calculated relative to 4 instead of $\pi_i$.

Thanks to Lance Bailey for suggesting this idea.

## example

Consider the starting sequence in $\pi = 31415...$. The 4 neighbours of the 3rd digit $\pi_3=4$ are (3, 1, 1, 5). The differences between its neighbours and $\pi_3 = 4$ are $-1$, $-3$, $-3$ and $1$. So at this position, the average is the $i$-ness and is $-1.5$ with a standard deviation of $1.7$.

If we calculate the difference relative to a fixed number (e.g. 5), we get the 5-ness of $\pi$. For the position $\pi_3$ the 5-ness is the average of the differences between the neighbour digits and 5. These differences are $-2$, $-4$, $-4$ and 0. The average value here is $-2.5$ with a standard deviation of $1.9$.

The iness of $\pi$. (posters)

In the $i$-ness of $\pi$ poster shown above, the average is mapped onto a color and the standard deviation onto size.

Based on the color you can tell how far away from 4 the neighbours are. Brown 4s have smaller neighbours and blue/green 4s have larger ones, on average.

## design

The type face of the main digits is Gotham. Index annotation is set in The Sans Mono Condensed Light and the neighbour and statistics annotations in Inconsolata.

VIEW ALL

# Analyzing outliers: Robust methods to the rescue

Sat 30-03-2019
Robust regression generates more reliable estimates by detecting and downweighting outliers.

Outliers can degrade the fit of linear regression models when the estimation is performed using the ordinary least squares. The impact of outliers can be mitigated with methods that provide robust inference and greater reliability in the presence of anomalous values.

Nature Methods Points of Significance column: Analyzing outliers: Robust methods to the rescue. (read)

We discuss MM-estimation and show how it can be used to keep your fitting sane and reliable.

Greco, L., Luta, G., Krzywinski, M. & Altman, N. (2019) Points of significance: Analyzing outliers: Robust methods to the rescue. Nature Methods 16:275–276.

Altman, N. & Krzywinski, M. (2016) Points of significance: Analyzing outliers: Influential or nuisance. Nature Methods 13:281–282.

# Two-level factorial experiments

Fri 22-03-2019
To find which experimental factors have an effect, simultaneously examine the difference between the high and low levels of each.

Two-level factorial experiments, in which all combinations of multiple factor levels are used, efficiently estimate factor effects and detect interactions—desirable statistical qualities that can provide deep insight into a system.

They offer two benefits over the widely used one-factor-at-a-time (OFAT) experiments: efficiency and ability to detect interactions.

Nature Methods Points of Significance column: Two-level factorial experiments. (read)

Since the number of factor combinations can quickly increase, one approach is to model only some of the factorial effects using empirically-validated assumptions of effect sparsity and effect hierarchy. Effect sparsity tells us that in factorial experiments most of the factorial terms are likely to be unimportant. Effect hierarchy tells us that low-order terms (e.g. main effects) tend to be larger than higher-order terms (e.g. two-factor or three-factor interactions).

Smucker, B., Krzywinski, M. & Altman, N. (2019) Points of significance: Two-level factorial experiments Nature Methods 16:211–212.

Krzywinski, M. & Altman, N. (2014) Points of significance: Designing comparative experiments.. Nature Methods 11:597–598.

# Happy 2019 $\pi$ Day—Digits, internationally

Tue 12-03-2019

Celebrate $\pi$ Day (March 14th) and set out on an exploration explore accents unknown (to you)!

This year is purely typographical, with something for everyone. Hundreds of digits and hundreds of languages.

A special kids' edition merges math with color and fat fonts.

116 digits in 64 languages. (details)
223 digits in 102 languages. (details)

Check out art from previous years: 2013 $\pi$ Day and 2014 $\pi$ Day, 2015 $\pi$ Day, 2016 $\pi$ Day, 2017 $\pi$ Day and 2018 $\pi$ Day.

# Tree of Emotional Life

Sun 17-02-2019

One moment you're $:)$ and the next you're $:-.$

Make sense of it all with my Tree of Emotional life—a hierarchical account of how we feel.

A section of the Tree of Emotional Life.

# Find and snap to colors in an image

Sat 29-12-2018

One of my color tools, the $colorsnap$ application snaps colors in an image to a set of reference colors and reports their proportion.

Below is Times Square rendered using the colors of the MTA subway lines.

Colors used by the New York MTA subway lines.

Times Square in New York City.
Times Square in New York City rendered using colors of the MTA subway lines.
Granger rainbow snapped to subway lines colors from four cities. (zoom)

# Take your medicine ... now

Wed 19-12-2018

Drugs could be more effective if taken when the genetic proteins they target are most active.

Design tip: rediscover CMYK primaries.

More of my American Scientific Graphic Science designs

Ruben et al. A database of tissue-specific rhythmically expressed human genes has potential applications in circadian medicine Science Translational Medicine 10 Issue 458, eaat8806.