Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - contact me Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Genome Sciences Center / mkweb.bcgsc.ca - Lumondo Photography
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science: fun


Circos at British Library Beautiful Science exhibit—Feb 20–May 26


design + visualization

EMBO Journal 2011 Cover Contest

non-scientific image entry - fiber optics - honourable mention

For the EMBO Journal 2011 Cover Contest, I prepared two entries, one for the scientific category and one for the non-scientific category.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The non-scientific entry is abstract photo of fiber optics. The scientific entry was an information graphic showing a hive panel of genomic annotations in human, mouse and dog genomes. The hive panel is based on the use of the newly introduced hive plot.

About the EMBO Journal Cover Contest

The EMBO Journal non-scientific cover prize is awarded for the most interesting and beautiful image made outside the lab. Contestants may submit, for example, photos or artistic impressions of wildlife animals, plants or landscapes. Particularly welcome will also be hand or computer-generated paintings or drawings (or photographs of other works of art) related to a biological or molecular biological topic.

The EMBO Journal scientific cover prize is awarded for the most captivating and thought-provoking contribution depicting a piece of molecular biology research. Entries can include light or electron micrographs, 3D reconstructions or models of biological specimen or molecules, spectacular artefacts collected in the lab, original new views of lab equipment (but not of colleagues!), or other research-based images to be of interest to molecular biologists.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Examples of scientific cover image winners from previous years. My Circos image (top left) won the 2010 scientfic image cover category. (see more)

2011 Contest and Image Status

The 2011 winners have been announced. The scientific image winner was Heiti Paves, who submitted a confocal image of an Arabidopsis thaliana anther filled with pollen grains. The non-scientific winner was Dieter Lampl, with his "Blue Ice" photo — a glacier in Los Glaciares National Park in Patagonia.

My non-scientific entry (photo of fiber optics) received honourable mention and was included in the Favourites of the Jury gallery.


non-scientific image entry - fiber Optics

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Four genomes — The illustration, originally part of a poster, shows syntenic relationships between human, chimpanzee, mouse and zebrafish genomes. Curved links encode sequence similarity and outer data tracks represent consensus similarity statistics and orthologous genes. The cover image shows a detail of a visualization prepared with the free genome comparison tool, Circos. (EMBO Journal - Best Scientific Cover - 2010)
Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My 2011 non-scientific fiber optic entry appears in a gallery of a small selection of images that were shortlisted by the jury of The EMBO Journal Cover Contest 2011. Images were selected with the aim of highlighting the diversity and quality of submissions in both, the scientific and non-scientific categories of the contest. (view gallery)

My non-scientific entry was an abstract image photo of fiber optics. It received honourable mention and were included in the Favourites of the Jury gallery.

The motivation and technical details behind these photos are described here.

The other entry, a scientific image, was an information graphic showing a hive panel of genomic annotations in human, mouse and dog genomes, based on the use of the newly introduced hive plot.

My submission of a large Circos figure for its cover (see right), which was originally designed for a poster that introduced Circos, was awarded the 2010 EMBO Journal best scientific cover prize.

entry details

Some time ago, I did a personal project of photos of fiber optic strands. These worked out well. I had not done anything with these images, and thought they would make a competitive entry into the cover contest.

Fiber optic lamp photos / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
My first attempt at photographing fiber optic lamp strands. These images were bundled into a set called Diving Horror, because of their likeness to creepy tentacles of creatures of the deep. (more images on flickr.)

I revisited the fiber optic lamp with a higher resolution camera (Canon 5D — original images were from a Canon 20D) and a dedicated macro lens (Sigma 150mm f2.8 EX APO DG HSM Macro) (original images were shot with the Canon EF 24-70L).

From these new images, shown below, I created five EMBO Journal cover submissions.

Fiber optic lamp photos / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Second attempt at photographing fiber optic lamp strands. (more images on flickr.)

The submissions would render on the cover as shown below.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Photos of fiber optic lamp strands. (More images on flickr.)

2011 EMBO Journal cover contest — fiber optic lamp submission images

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2011 EMBO Cover contest submission — macro photograph of fiber optic lamp strands. (More images on flickr.)

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2011 EMBO Cover contest submission — macro photograph of fiber optic lamp strands. (More images on flickr.)

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2011 EMBO Cover contest submission — macro photograph of fiber optic lamp strands. (More images on flickr.)

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2011 EMBO Cover contest submission — macro photograph of fiber optic lamp strands. (More images on flickr.)

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
2011 EMBO Cover contest submission — macro photograph of fiber optic lamp strands. (More images on flickr.)

news + thoughts

Happy Pi Approximation Day— π, roughly speaking 10,000 times

Wed 23-07-2014

Celebrate Pi Approximation Day (July 22nd) with the art arm waving. This year I take the first 10,000 most accurate approximations (m/n, m=1..10,000) and look at their accuracy.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Accuracy of the first 10,000 m/n approximations of Pi. (details)

I turned to the spiral again after applying it to stack stacked ring plots of frequency distributions in Pi for the 2014 Pi Day.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Frequency distribution of digits of Pi in groups of 4 up to digit 4,988. (details)

Analysis of Variance (ANOVA) and Blocking—Accounting for Variability in Multi-factor Experiments

Mon 07-07-2014

Our 10th Points of Significance column! Continuing with our previous discussion about comparative experiments, we introduce ANOVA and blocking. Although this column appears to introduce two new concepts (ANOVA and blocking), you've seen both before, though under a different guise.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Analysis of variance (ANOVA) and blocking. (read)

If you know the t-test you've already applied analysis of variance (ANOVA), though you probably didn't realize it. In ANOVA we ask whether the variation within our samples is compatible with the variation between our samples (sample means). If the samples don't all have the same mean then we expect the latter to be larger. The ANOVA test statistic (F) assigns significance to the ratio of these two quantities. When we only have two-samples and apply the t-test, t2 = F.

ANOVA naturally incorporates and partitions sources of variation—the effects of variables on the system are determined based on the amount of variation they contribute to the total variation in the data. If this contribution is large, we say that the variation can be "explained" by the variable and infer an effect.

We discuss how data collection can be organized using a randomized complete block design to account for sources of uncertainty in the experiment. This process is called blocking because we are blocking the variation from a known source of uncertainty from interfering with our measurements. You've already seen blocking in the paired t-test example, in which the subject (or experimental unit) was the block.

We've worked hard to bring you 20 pages of statistics primers (though it feels more like 200!). The column is taking a month off in August, as we shrink our error bars.

Krzywinski, M. & Altman, N. (2014) Points of Significance: Analysis of Variance (ANOVA) and Blocking Nature Methods 11:699-700.

Background reading

Krzywinski, M. & Altman, N. (2014) Points of Significance: Designing Comparative Experiments Nature Methods 11:597-598.

Krzywinski, M. & Altman, N. (2014) Points of Significance: Comparing Samples — Part I — t-tests Nature Methods 11:215-216.

Krzywinski, M. & Altman, N. (2013) Points of Significance: Significance, P values and t-tests Nature Methods 10:1041-1042.

...more about the Points of Significance column



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