Poetry is just the evidence of life. If your life is burning well, poetry is just the ashburn somethingmore quotes

# party: worth having

The Outbreak Poems — artistic emissions in a pandemic

# Genome Sciences Center 20th Anniversary Clothing, Music, Drinks and Art

On 15 November 2019, the Genome Sciences Center held its 20th anniversary celebration.

Here you can read about the design of the evening's clothing, music, drinks and other art.

Biology is the only science in which multiplication means the same thing as division.

## flow cells

A closeup of the mount of an 8-lane Illumina flow cell. (zoom)

### Illumina flow cells

An 8-lane Illumina flow cell from Canada’s Michael Smith Genome Sciences Centre’s sequencing lab. Using a patterned array of billions of nanowells and sequencing-by-synthesis, this flow cell is capable of collecting up to 1,200,000,000,000 bases in reads of 150 bases from up to 8 independent samples in 73 hours.

Mounted and framed Illumina flow cell H3JM3CCX2 containing the sequence of a human lymph node sample from a patient with high-grade B cell lymphoma. (zoom)
Mounted and framed Illumina flow cell H3JM3CCX2 containing the sequence of a human lymph node sample from a patient with high-grade B cell lymphoma. (zoom)
Mounted and framed Illumina flow cell H3JM3CCX2 containing the sequence of a human lymph node sample from a patient with high-grade B cell lymphoma. (zoom)
Mounted and framed Illumina flow cell H3JM3CCX2 containing the sequence of a human lymph node sample from a patient with high-grade B cell lymphoma. (zoom)
Mounted and framed Illumina flow cell H3JM3CCX2 containing the sequence of a human lymph node sample from a patient with high-grade B cell lymphoma. (zoom)
Mounted and framed Illumina flow cell H3JM3CCX2 containing the sequence of a human lymph node sample from a patient with high-grade B cell lymphoma. (zoom)
Mounted and framed Illumina flow cell H3JM3CCX2 containing the sequence of a human lymph node sample from a patient with high-grade B cell lymphoma. (zoom)

### PromethION flow cells

An Oxford Nanopore Technologies PromethION flow cell from Canada’s Michael Smith Genome Sciences Centre’s sequencing lab. Using protein nanopores embedded in a membrane, this flow cell is capable of sequencing up to 75,000,000,000 bases in read lengths ranging from 100 to 300,000 bases in 72 hours with high accuracy across repetitive regions of a genome. A PriomethION sequencer can process up to 24 flow cells in parallel.

Mounted and framed PrometION flow cell FAK22538 containing the sequence of a Yellow-bellied Marmot. (zoom)
Mounted and framed PrometION flow cell FAK22538 containing the sequence of a Yellow-bellied Marmot. (zoom)
Mounted and framed PrometION flow cell FAK22538 containing the sequence of a Yellow-bellied Marmot. (zoom)
Mounted and framed PrometION flow cell FAK22538 containing the sequence of a Yellow-bellied Marmot. (zoom)
Mounted and framed PrometION flow cell FAK22538 containing the sequence of a Yellow-bellied Marmot. (zoom)

### MinION flow cells

An Oxford Nanopore Technologies MinION flow cell from Canada’s Michael Smith Genome Sciences Centre’s sequencing lab. Using protein nanopores embedded in a membrane, this flow cell is capable of sequencing up to 16,000,000,000 bases in read lengths ranging from 100 to 300,000 bases in 72 hours. Able to accurately sequence across repetitive regions of a genome, this MinION sequencer can fit in the palm of your hand and runs over USB.

Mounted and framed MinION flow cell PAD93784 containing the sequence of a human peripheral blood sample from a patient with Duchenne Muscular Dystrophy genome. (zoom)
Mounted and framed MinION flow cell PAD93784 containing the sequence of a human peripheral blood sample from a patient with Duchenne Muscular Dystrophy genome. (zoom)
Mounted and framed MinION flow cell PAD93784 containing the sequence of a human peripheral blood sample from a patient with Duchenne Muscular Dystrophy genome. (zoom)
Mounted and framed MinION flow cell PAD93784 containing the sequence of a human peripheral blood sample from a patient with Duchenne Muscular Dystrophy genome. (zoom)
Mounted and framed MinION flow cell PAD93784 containing the sequence of a human peripheral blood sample from a patient with Duchenne Muscular Dystrophy genome. (zoom)
Mounted and framed MinION flow cell PAD93784 containing the sequence of a human peripheral blood sample from a patient with Duchenne Muscular Dystrophy genome. (zoom)
The plaque at the back of a framed MinION flow cell. This one has sequence from the Yellow-bellied Marmot. (zoom)

### engineering drawings of flow cell mounts

Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)
Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)
Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)
Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)
Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)
Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)
Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)
Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)
Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)
Engineering drawings of flow cell mounts. Conceptualized and prepared by Robin Coope. (zoom)

# Points of Significance celebrates 50th column

Mon 24-08-2020

We are celebrating the publication of our 50th column!

To all our coauthors — thank you and see you in the next column!

Nature Methods Points of Significance: Celebrating 50 columns of clear explanations of statistics. (read)

# Uncertainty and the management of epidemics

Mon 24-08-2020

When modelling epidemics, some uncertainties matter more than others.

Public health policy is always hampered by uncertainty. During a novel outbreak, nearly everything will be uncertain: the mode of transmission, the duration and population variability of latency, infection and protective immunity and, critically, whether the outbreak will fade out or turn into a major epidemic.

The uncertainty may be structural (which model?), parametric (what is $R_0$?), and/or operational (how well do masks work?).

This month, we continue our exploration of epidemiological models and look at how uncertainty affects forecasts of disease dynamics and optimization of intervention strategies.

Nature Methods Points of Significance column: Uncertainty and the management of epidemics. (read)

We show how the impact of the uncertainty on any choice in strategy can be expressed using the Expected Value of Perfect Information (EVPI), which is the potential improvement in outcomes that could be obtained if the uncertainty is resolved before making a decision on the intervention strategy. In other words, by how much could we potentially increase effectiveness of our choice (e.g. lowering total disease burden) if we knew which model best reflects reality?

This column has an interactive supplemental component (download code) that allows you to explore the impact of uncertainty in $R_0$ and immunity duration on timing and size of epidemic waves and the total burden of the outbreak and calculate EVPI for various outbreak models and scenarios.

Nature Methods Points of Significance column: Uncertainty and the management of epidemics. (Interactive supplemental materials)

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: Uncertainty and the management of epidemics. Nature Methods 17.

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: Modeling infectious epidemics. Nature Methods 17:455–456.

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: The SEIRS model for infectious disease dynamics. Nature Methods 17:557–558.

# Cover of Nature Genetics August 2020

Mon 03-08-2020

Our design on the cover of Nature Genetics's August 2020 issue is “Dichotomy of Chromatin in Color” . Thanks to Dr. Andy Mungall for suggesting this terrific title.

Dichotomy of Chromatin in Color. Nature Genetics, August 2020 issue. (read more)

The cover design accompanies our report in the issue Gagliardi, A., Porter, V.L., Zong, Z. et al. (2020) Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes. Nature Genetics 52:800–810.

# Poster Design Guidelines

Wed 15-07-2020

Clear, concise, legible and compelling.

The PDF template is a poster about making posters. It provides design, typography and data visualiation tips with minimum fuss. Follow its advice until you have developed enough design sobriety and experience to know when to go your own way.

Poster Design Guidelines — Clear, concise, legible and compelling..

# The SEIRS model for infectious disease dynamics

Thu 18-06-2020

Realistic models of epidemics account for latency, loss of immunity, births and deaths.

We continue with our discussion about epidemic models and show how births, deaths and loss of immunity can create epidemic waves—a periodic fluctuation in the fraction of population that is infected.

Nature Methods Points of Significance column: The SEIRS model for infectious disease dynamics. (read)

This column has an interactive supplemental component (download code) that allows you to explore epidemic waves and introduces the idea of the phase plane, a compact way to understand the evolution of an epidemic over its entire course.

Nature Methods Points of Significance column: The SEIRS model for infectious disease dynamics. (Interactive supplemental materials)

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: The SEIRS model for infectious disease dynamics. Nature Methods 17:557–558.