Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - contact me Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca on Twitter Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Lumondo Photography Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Art Martin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Hilbertonians - Creatures on the Hilbert CurveMartin Krzywinski / Canada's Michael Smith Genome Sciences Centre / mkweb.bcgsc.ca - Pi Day 2020 - Piku
Here we are now at the middle of the fourth large part of this talk.Pepe Deluxeget nowheremore quotes

20th: join us


Scientific graphical abstracts — design guidelines


data visualization + celebration

Genome Sciences Center 20th Anniversary Clothing, Music, Drinks and Art

On 15 November 2019, the Genome Sciences Center held its 20th anniversary celebration.

Here you can read about the design of the evening's clothing, music, drinks and other art.

Distrust any enterprise that requires new clothes.
— Henry David Thoreau (Walden)

clothing

BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Luke and Mayia wearing limited edition volunteer t-shirts. The pattern reproduces the human genome with chromosomes as spirals. (zoom)
BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dr. Mungall revealing his personal side: DNA socks. In his hand, the 'improved outcome', one of the signature cocktails created for the celebration. (zoom)
BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Paul and Nazanin show off their party swag. (zoom)

t-shirt

BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The relative lengths of human chromosomes. (zoom)
BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Human chromosomes proportionately represented as spirals. Maybe you can notice something about the start and direction of each spiral. (zoom)
BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Chromosome spirals snuggled into a square. (zoom)
BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Chromosome spiral t-shirt design. (zoom)
BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Knitted tag signalling the authenticity of the anniversary swag. (zoom)

socks

BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Left- and right-handed forms of DNA. (zoom)
BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dimensions of the DNA molecule. (zoom)
BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Sock design. The left sock DNA is left-handed and the right sock DNA is right-handed. (zoom)
BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The knitted socks, as they should be worn. The dots at the small toe indicate the left and right socks. (zoom)

hoodie

BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Warm and cozy hoodie has the GSC logo unwound on the left arm. The anniversary patch is on the back right. (zoom)

lanyard

BC Cancer Genome Sciences Center 20th Anniversary Celebration / Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
The lanyard shows two DNA helices zipping up.

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news + thoughts

Graphical Abstract Design Guidelines

Fri 13-11-2020

Clear, concise, legible and compelling.

Making a scientific graphical abstract? Refer to my practical design guidelines and redesign examples to improve organization, design and clarity of your graphical abstracts.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Graphical Abstract Design Guidelines — Clear, concise, legible and compelling.

"This data might give you a migrane"

Tue 06-10-2020

An in-depth look at my process of reacting to a bad figure — how I design a poster and tell data stories.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
A poster of high BMI and obesity prevalence for 185 countries.

He said, he said — a word analysis of the 2020 Presidential Debates

Thu 01-10-2020

Building on the method I used to analyze the 2008, 2012 and 2016 U.S. Presidential and Vice Presidential debates, I explore word usagein the 2020 Debates between Donald Trump and Joe Biden.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Analysis of word usage by parts of speech for Trump and Biden reveals insight into each candidate.

Points of Significance celebrates 50th column

Mon 24-08-2020

We are celebrating the publication of our 50th column!

To all our coauthors — thank you and see you in the next column!

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance: Celebrating 50 columns of clear explanations of statistics. (read)

Uncertainty and the management of epidemics

Mon 24-08-2020

When modelling epidemics, some uncertainties matter more than others.

Public health policy is always hampered by uncertainty. During a novel outbreak, nearly everything will be uncertain: the mode of transmission, the duration and population variability of latency, infection and protective immunity and, critically, whether the outbreak will fade out or turn into a major epidemic.

The uncertainty may be structural (which model?), parametric (what is `R_0`?), and/or operational (how well do masks work?).

This month, we continue our exploration of epidemiological models and look at how uncertainty affects forecasts of disease dynamics and optimization of intervention strategies.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Uncertainty and the management of epidemics. (read)

We show how the impact of the uncertainty on any choice in strategy can be expressed using the Expected Value of Perfect Information (EVPI), which is the potential improvement in outcomes that could be obtained if the uncertainty is resolved before making a decision on the intervention strategy. In other words, by how much could we potentially increase effectiveness of our choice (e.g. lowering total disease burden) if we knew which model best reflects reality?

This column has an interactive supplemental component (download code) that allows you to explore the impact of uncertainty in `R_0` and immunity duration on timing and size of epidemic waves and the total burden of the outbreak and calculate EVPI for various outbreak models and scenarios.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Nature Methods Points of Significance column: Uncertainty and the management of epidemics. (Interactive supplemental materials)

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: Uncertainty and the management of epidemics. Nature Methods 17.

Background reading

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: Modeling infectious epidemics. Nature Methods 17:455–456.

Bjørnstad, O.N., Shea, K., Krzywinski, M. & Altman, N. (2020) Points of significance: The SEIRS model for infectious disease dynamics. Nature Methods 17:557–558.

Cover of Nature Genetics August 2020

Mon 03-08-2020

Our design on the cover of Nature Genetics's August 2020 issue is “Dichotomy of Chromatin in Color” . Thanks to Dr. Andy Mungall for suggesting this terrific title.

Martin Krzywinski @MKrzywinski mkweb.bcgsc.ca
Dichotomy of Chromatin in Color. Nature Genetics, August 2020 issue. (read more)

The cover design accompanies our report in the issue Gagliardi, A., Porter, V.L., Zong, Z. et al. (2020) Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes. Nature Genetics 52:800–810.